Year-by-year White Matter Hyperintensity Probabilistic Atlases based on China Aging Cohort and its Application to Cognitive Decline Evaluation
2024-01-26
会议录名称INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE 2024
发表状态已发表
摘要

Motivation: As frequently observed in older populations, white matter hyperintensity (WMH) appears a risk factor for cognitive decline.

Goal(s): To construct normative WMH probabilistic atlases for quantifying its spatiotemporal progression and for disease detection.

Approach: We released the first set of such atlases and related trajectories, based on a large cohort of the Chinese typical aging population, with AI techniques.

Results: We validated its clinical usefulness by comparing cognitive impairment groups with the atlases, as a new tool for early Alzheimer’s disease evaluation. We also found that the WMH in deep, rather than periventricular, white matter moderated aging- induced general cognitive ability reduction.

Impact: Given normative curves summarizing WHM progression in Chinese typical aging population, clinicians can better assess abnormalities related to cerebral small-vessel diseases, detect high-risk individuals who will develop cognitive decline in the future, and conduct large-scale community screening for older population.

语种英语
文献类型会议论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/493554
专题信息科学与技术学院_硕士生
生物医学工程学院
生物医学工程学院_公共科研平台_智能医学科研平台
生物医学工程学院_PI研究组_张寒组
通讯作者Han Zhang
作者单位
1.School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
2.The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3.Shanghai Clinical Research and Trial Center, Shanghai, China
第一作者单位生物医学工程学院
通讯作者单位生物医学工程学院
第一作者的第一单位生物医学工程学院
推荐引用方式
GB/T 7714
Xinyi Cai,Peiyu Huang,Xiao Luo,et al. Year-by-year White Matter Hyperintensity Probabilistic Atlases based on China Aging Cohort and its Application to Cognitive Decline Evaluation[C],2024.
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