RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice

doi:10.1016/j.molcel.2019.03.013

	RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice
	Zhai, Keran 1,2; Deng, Yiwen 1; Liang, Di 1,2; Tang, Jun 1,2; Liu, Jing 1,2; Yan, Bingxiao 1,2; Yin, Xin 1; Lin, Hui3 ; Chen, Fudan 4; Yang, Dongyong 1,2; Xie, Zhen 4; Liu, Ji-Yun 1; Li, Qun 1; Zhang, Lin 5; He, Zuhua 1,4
	2019-06-06
发表期刊	MOLECULAR CELL (IF:14.5[JCR-2023],16.6[5-Year])
ISSN	1097-2765
卷号	74 期号:5 页码:996-+
发表状态	已发表
DOI	10.1016/j.molcel.2019.03.013
摘要	Nucleotide-binding site leucine-rich repeat (NLR) receptors perceive pathogen effectors and trigger plant immunity. However, the mechanisms underlying NLR-triggered defense responses remain obscure. The recently discovered Pigm locus in rice encodes a cluster of NLRs, including PigmR, which confers broad-spectrum resistance to blast fungus. Here, we identify PIBP1 (PigmR-INTERACTING and BLAST RESISTANCE PROTEIN 1), an RRM (RNA-recognition motif) protein that specifically interacts with PigmR and other similar NLRs to trigger blast resistance. PigmR-promoted nuclear accumulation of PIBP1 ensures full blast resistance. We find that PIBP1 and a homolog, Os06 g02240, bind DNA and function as unconventional transcription factors at the promoters of the defense genes OsWAK14 and OsPAL1, activating their expression. Knockout of PIBP1 and Os06 g02240 greatly attenuated blast resistance. Collectively, our study discovers previously unappreciated RRM transcription factors that directly interact with NLRs to activate plant defense, establishing a direct link between transcriptional activation of immune responses with NLR-mediated pathogen perception.
收录类别	SCI ; SCIE
语种	英语
资助项目	Chinese Academy of Sciences[XDB27040201]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000470249100013
出版者	CELL PRESS
WOS关键词	PATHOGEN EFFECTORS ; ARABIDOPSIS EDS1 ; INNATE IMMUNITY ; FLOWERING-TIME ; PROTEIN ; GENE ; RECEPTORS ; DEFENSE ; SYSTEM ; PLANTS
原始文献类型	Article
引用统计	被引频次：92[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/49000
专题	生命科学与技术学院_博士生
通讯作者	He, Zuhua
作者单位	1.Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou, Zhejiang, Peoples R China 5.Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Yangzhou, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Zhai, Keran,Deng, Yiwen,Liang, Di,et al. RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice[J]. MOLECULAR CELL,2019,74(5):996-+.
APA	Zhai, Keran.,Deng, Yiwen.,Liang, Di.,Tang, Jun.,Liu, Jing.,...&He, Zuhua.(2019).RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice.MOLECULAR CELL,74(5),996-+.
MLA	Zhai, Keran,et al."RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice".MOLECULAR CELL 74.5(2019):996-+.