CHML promotes liver cancer metastasis by facilitating Rab14 recycle

doi:10.1038/s41467-019-10364-0

	CHML promotes liver cancer metastasis by facilitating Rab14 recycle
	Chen, Tian-Wei 1,2,3; Yin, Fen-Fen 1,2; Yuan, Yan-Mei 1,2; Guan, Dong-Xian 1; Zhang, Erbin 1,2; Zhang, Feng-Kun 1,2; Jiang, Hao 1,2; Ma, Ning 1,2; Wang, Jing-Jing 1; Ni, Qian-Zhi 1,2; Qiu, Lin 1; Feng, Jing 3; Zhang, Xue-Li 3; Bao, Ying 4; Wang, Kang 5; Cheng, Shu-Qun 5; Wang, Xiao-Fan 6; Wang, Xiang 7; Li, Jing-Jing 1,2; Xie, Dong1,2,8,9
	2019-06-07
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	10
发表状态	已发表
DOI	10.1038/s41467-019-10364-0
摘要	Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31601143] ; National Natural Science Foundation of China[31520103907] ; National Natural Science Foundation of China[81730083] ; National Natural Science Foundation of China[31771538]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000470656800018
出版者	NATURE PUBLISHING GROUP
WOS关键词	HEPATOCELLULAR-CARCINOMA ; PHAGOSOME MATURATION ; CELL-PROLIFERATION ; CHOROIDEREMIA ; COMPLEX ; GERANYLGERANYLATION ; PROTEINS ; GTPASES ; DISSOCIATION ; TRAFFICKING
原始文献类型	Article
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/48993
专题	生命科学与技术学院_特聘教授组_谢东组
通讯作者	Wang, Xiao-Fan; Wang, Xiang; Li, Jing-Jing; Xie, Dong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Xuhui Dist 200031, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Xuhui Dist 200031, Peoples R China 3.Southern Med Univ, Fengxian Hosp, Dept Gen Surg, 6600 Nanfeng Rd, Shanghai 201499, Peoples R China 4.Huzhou Univ, Peoples Hosp Affiliated 1, Dept Surg, Huzhou 313000, Peoples R China 5.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 6, Changhai Rd 225, Shanghai 200438, Peoples R China 6.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA 7.Huzhou Univ, Peoples Hosp Affiliated 1, Key Lab Translat Med, Huzhou 313000, Peoples R China 8.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China 9.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Tian-Wei,Yin, Fen-Fen,Yuan, Yan-Mei,et al. CHML promotes liver cancer metastasis by facilitating Rab14 recycle[J]. NATURE COMMUNICATIONS,2019,10.
APA	Chen, Tian-Wei.,Yin, Fen-Fen.,Yuan, Yan-Mei.,Guan, Dong-Xian.,Zhang, Erbin.,...&Xie, Dong.(2019).CHML promotes liver cancer metastasis by facilitating Rab14 recycle.NATURE COMMUNICATIONS,10.
MLA	Chen, Tian-Wei,et al."CHML promotes liver cancer metastasis by facilitating Rab14 recycle".NATURE COMMUNICATIONS 10(2019).