Enantioselective palladium-catalyzed C(sp(2))-H carbamoylation

doi:10.1016/j.tet.2019.03.038

	Enantioselective palladium-catalyzed C(sp(2))-H carbamoylation
	Dong, Wenfeng1 ; Xu, Guangqing 2; Tang, Wenjun1,2
	2019-06-14
发表期刊	TETRAHEDRON (IF:2.1[JCR-2023],1.8[5-Year])
ISSN	0040-4020
卷号	75 期号:24 页码:3239-3247
发表状态	已发表
DOI	10.1016/j.tet.2019.03.038
摘要	An enantioselective palladium-catalyzed C(sp(2))-H carbamoylation for the preparation of chiral iso-indolines was described for the first time. With chiral monophosphorus ligand (R)-AntPhos as the ligand, a series of chiral isoindolines were prepared from diarylmethyl carbamoyl chlorides in excellent yields and enantioselectivities with the palladium loading as low as 1 mol%. Initial mechanistic studies indicated the asymmetric cyclization catalyzed a palladium species with a single chiral monophosphorus ligand. (C) 2019 Elsevier Ltd. All rights reserved.
关键词	Carbamoylation Enantioselective Isoindolines Palladium catalysis Chiral phosphorus ligand
收录类别	SCI ; SCIE ; IC ; CCR
语种	英语
资助项目	NSFC[21725205] ; NSFC[21432007] ; NSFC[21572246] ; NSFC[21702223]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000471208400012
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	INTRAMOLECULAR ALKANE ARYLATION ; CHIRAL MONOPHOSPHORUS LIGANDS ; ASYMMETRIC-SYNTHESIS ; BETA-LACTAMS ; STEREOSELECTIVE-SYNTHESIS ; EFFICIENT SYNTHESES ; C(SP(3))-H ; ACTIVATION ; ACCESS ; MECHANISM
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/48965
专题	物质科学与技术学院_博士生物质科学与技术学院_特聘教授组_汤文军组
通讯作者	Tang, Wenjun
作者单位	1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Ling Ling Rd, Shanghai 200032, Peoples R China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Dong, Wenfeng,Xu, Guangqing,Tang, Wenjun. Enantioselective palladium-catalyzed C(sp(2))-H carbamoylation[J]. TETRAHEDRON,2019,75(24):3239-3247.
APA	Dong, Wenfeng,Xu, Guangqing,&Tang, Wenjun.(2019).Enantioselective palladium-catalyzed C(sp(2))-H carbamoylation.TETRAHEDRON,75(24),3239-3247.
MLA	Dong, Wenfeng,et al."Enantioselective palladium-catalyzed C(sp(2))-H carbamoylation".TETRAHEDRON 75.24(2019):3239-3247.