上海科技大学知识管理系统

一种式(I)所示的磺酰胺类化合物或者其药学上可接受的盐、其互变异构体或其立体异构体作为WDR5抑制剂的用途，具有显著的WDR5与Myc的相互作用阻断剂作用，有助于癌症治疗。 A 1和A 2为环结构，R 1和R 2为取代基。

The use of a sulfonamide compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, or a stereoisomer thereof as a WDR5 inhibitor. The compound has a significant effect as a WDR5 and Myc interaction blocker, and is conducive to cancer treatment. A1 and A2 are ring structures, and R1 and R2 are substituents.