上海科技大学知识管理系统

一种式(I)所示的磺酰胺类化合物或者其药学上可接受的盐、其互变异构体或其立体异构体及其制备方法和用途，及其药物组合物。该化合物作为WDR5抑制剂，具有显著的WDR5与Myc的相互作用阻断剂作用，有助于癌症治疗，，A 1和A 2为环结构，R 1和R 2为取代基。

A sulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, a preparation method for same and a use of same, and a pharmaceutical composition comprising same. The compound serves as a WDR5 inhibitor, has a remarkable effect as a WDR5 and Myc interaction blocker, and is beneficial to cancer treatment. A1 and A2 each are of a ring structure, and R1 and R2 are substituents.