Osteoporosis with different causation exhibits different changes in bone tissue mineral and organic matrix

doi:10.1101/2024.12.25.630292

	Osteoporosis with different causation exhibits different changes in bone tissue mineral and organic matrix
	Lin, Jing-Yu1,2 ; Guo, Xu2 ; Sun, Ming-Hui2 ; Zhang, Yifeng2,3 ; Lu, Jun-Xia 1
	2024-12-25
状态	已发表
摘要	Osteoporosis (OP) which is a common skeletal disease with different causation is prevalent in aging population. Postmenopause women generally suffer from OP with bone loss due to estrogen deficiency. Diabetes are also associated with OP by complex metabolic mechanisms. Bone qualities of OP caused by aging were compared with the ovariectomy (OVX) model and the Type 2 diabetic model using Sprague-Dawley (SD) rats in our study. Combining with micro-computed tomography (Âµ-CT) and solid-state NMR (SSNMR) methods, this research studied bone changes in SD rats from tissue level to the molecular level. The studies revealed bone loss was most significant for cancellous bones, but not for cortical bones in OP rats. However, at the molecular level, the content of HAP in cortical bone increased with aging, contributing to the brittleness of the bone. Triglyceride, as a senescence maker of osteocyte in cortical bone, was also identified to be closely associated with OP in aging and OVX rats, but not in diabetic rats. This research suggests differing bone qualities in molecular level of OP with various causes more objectively reflect the bone tissue reconstruction rather than bone loss in Âµ-CT analysis.
语种	英语
DOI	10.1101/2024.12.25.630292
相关网址	查看原文
出处	bioRxiv
收录类别	PPRN.PPRN
WOS记录号	PPRN:120139249
WOS类目	Biochemistry & Molecular Biology
资助项目	ShanghaiTech University[2019F0202-000-01] ; Natural Science Foundation of Shanghai[20ZR1437000] ; Natural Science Foundation of China["32171185","31770790"]
文献类型	预印本
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/483986
专题	生命科学与技术学院生命科学与技术学院_硕士生生命科学与技术学院_博士生生命科学与技术学院_PI研究组_张翼锋组上海临床研究中心
通讯作者	Zhang, Yifeng; Lu, Jun-Xia
作者单位	1.Wuhan Univ Sci & Technol, Interdisciplinary Inst NMR & Mol Sci, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.ShanghaiTech Univ, Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Lin, Jing-Yu,Guo, Xu,Sun, Ming-Hui,et al. Osteoporosis with different causation exhibits different changes in bone tissue mineral and organic matrix. 2024.