A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain

doi:10.1101/2024.12.12.628265

	A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain
	Pu, Cong1,2 ; Fu, Ben1,2 ; Lu, Pengda1,2 ; Guan, Xin 3; Zhang, Jiayi1,2 ; Shen, Yuting 3; Li, Xiao 3; Guo, Lehang 4,5; Xu, Huixiong 3; Jiang, Xiaoning 6; Peng, Chang1,2
	2024-12-17
状态	已发表
摘要	Diabetic foot disease, a severe complication of diabetes, frequently results in diabetic neuropathic pain, which diminishes quality of life and increases the risk of amputation. Current treatment options are limited in their effectiveness and can present adverse effects. We have demonstrated a first-of-its-kind wearable spiral ultrasound patch for focused ultrasound peripheral neuromodulation to alleviate diabetic neuropathic pain. This innovative, stretchable ultrasound device reliably delivers focused ultrasound to peripheral nerves. The device's ultrasound elements are arranged in a phyllotaxis spiral pattern, enhancing transmitted acoustic focus performance and minimizing grating and side lobes. Using a diabetic foot rat model, we confirmed peripheral neuropathy through behavioral assessments of mechanical allodynia and heat hyperalgesia, which showed significant pain relief after two weeks of ultrasound treatment. Additionally, nerve conduction velocity improved. Biological safety tests indicated no adverse effects on nerve tissues or cells. Our approach offers a non-invasive solution for managing diabetic neuropathic pain and provides critical insights into its underlying mechanisms, paving the way for more effective therapies.
语种	英语
DOI	10.1101/2024.12.12.628265
相关网址	查看原文
出处	bioRxiv
收录类别	PPRN.PPRN
WOS记录号	PPRN:119959877
WOS类目	Engineering, Multidisciplinary
资助项目	Shanghai Sailing Program[22YF1428900] ; National Science Foundation of China["82151318","12204307"]
文献类型	预印本
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/483970
专题	生物医学工程学院信息科学与技术学院_硕士生信息科学与技术学院_博士生生物医学工程学院_PI研究组_彭畅组生物医学工程学院_硕士生
通讯作者	Peng, Chang
作者单位	1.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Inst Ultrasound Med & Engn, Dept Ultrasound, Shanghai 200032, Peoples R China 4.Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Ultrasound, Sch Med, Shanghai 200072, Peoples R China 5.Tongji Univ, Shanghai Peoples Hosp 10, Ctr Minimally Invas Treatment Tumor, Sch Med, Shanghai 200072, Peoples R China 6.North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695, USA
推荐引用方式 GB/T 7714	Pu, Cong,Fu, Ben,Lu, Pengda,et al. A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain. 2024.