Remote C(sp<SUP>3</SUP>)-H Carboxylation with CO<sub>2</sub> via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer

doi:10.1021/acs.orglett.4c04294

	Remote C(sp³)-H Carboxylation with CO₂ via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer
	Huang, Haoran 1,2; Lin, Xiaoyu1,2,3 ; Yang, Fanyuanhang 1; Ren, Yuxi 1; Gao, Yuzhen 1,2; Su, Weiping1,2,3
	2024-12-13
发表期刊	ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN	1523-7060
EISSN	1523-7052
卷号	26 期号:51
发表状态	已发表
DOI	10.1021/acs.orglett.4c04294
摘要	The direct carboxylation of C(sp3)-H bonds with CO2 represents a challenging but highly attractive strategy in organic synthesis. In this study, we presented a visible-light-catalyzed strategy for carboxylating remote C(sp3)-H bonds with CO2 via aryl radical induced 1,5-hydrogen atom transfer. This transformation involves generating alkyl radicals via 1,5-hydrogen atom transfer from aryl radicals, forming alkyl carbanions as key intermediates, and a subsequent nucleophilic attack with CO2, thereby enabling access to a variety of tertiary and quaternary carboxylic acids in moderate to good yields.
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收录类别	SCI
语种	英语
资助项目	Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China[
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:001377998700001
出版者	AMER CHEMICAL SOC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/471014
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_苏伟平组物质科学与技术学院_博士生
通讯作者	Gao, Yuzhen; Su, Weiping
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem,Fujian Sci & Technol Inn, Fuzhou 350002, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Huang, Haoran,Lin, Xiaoyu,Yang, Fanyuanhang,et al. Remote C(sp³)-H Carboxylation with CO₂ via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer[J]. ORGANIC LETTERS,2024,26(51).
APA	Huang, Haoran,Lin, Xiaoyu,Yang, Fanyuanhang,Ren, Yuxi,Gao, Yuzhen,&Su, Weiping.(2024).Remote C(sp³)-H Carboxylation with CO₂ via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer.ORGANIC LETTERS,26(51).
MLA	Huang, Haoran,et al."Remote C(sp³)-H Carboxylation with CO₂ via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer".ORGANIC LETTERS 26.51(2024).