Precise Protein Photolithography (P-3): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist
Liu, Wanpeng1; Zhou, Zhitao2,3; Zhang, Shaoqing1; Shi, Zhifeng4; Tabarini, Justin1; Lee, Woonsoo1; Zhang, Yeshun5; Corder, S. N. Gilbert6; Li, Xinxin2,3,7; Dong, Fei4; Cheng, Liang4; Liu, Mengkun6; Kaplan, David L.8; Omenetto, Fiorenzo G.8; Zhang, Guozheng5; Mao, Ying4; Tao, Tiger H.1,2,3,7
Source PublicationADVANCED SCIENCE
AbstractPrecise patterning of biomaterials has widespread applications, including drug release, degradable implants, tissue engineering, and regenerative medicine. Patterning of protein-based microstructures using UV-photolithography has been demonstrated using protein as the resist material. The Achilles heel of existing protein-based biophotoresists is the inevitable wide molecular weight distribution during the protein extraction/regeneration process, hindering their practical uses in the semiconductor industry where reliability and repeatability are paramount. A wafer-scale high resolution patterning of bio-microstructures using well-defined silk fibroin light chain as the resist material is presented showing unprecedent performances. The lithographic and etching performance of silk fibroin light chain resists are evaluated systematically and the underlying mechanisms are thoroughly discussed. The micropatterned silk structures are tested as cellular substrates for the successful spatial guidance of fetal neural stems cells seeded on the patterned substrates. The enhanced patterning resolution, the improved etch resistance, and the inherent biocompatibility of such protein-based photoresist provide new opportunities in fabricating large scale biocompatible functional microstructures.
Keywordbiopatterning protein photolithography silk fibroin light chain
Indexed BySCI
Funding ProjectNSF under CMMI Division[1563422] ; NSF under CMMI Division[1562915]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000411148100025
Original Document TypeArticle
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang, Guozheng; Mao, Ying; Tao, Tiger H.
Affiliation1.Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA
2.Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, State Key Lab Transducer Technol, Shanghai 200050, Peoples R China
3.Univ Chinese Sci Acad, Sch Grad Study, Beijing 100049, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Neurosurg, Wulumuqi Zhong Rd 12, Shanghai 200040, Peoples R China
5.Jiangsu Univ Sci & Technol, 2 Mengxi Rd, Zhenjiang 212003, Jiangsu, Peoples R China
6.SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA
7.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
8.Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA
Corresponding Author AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Liu, Wanpeng,Zhou, Zhitao,Zhang, Shaoqing,et al. Precise Protein Photolithography (P-3): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist[J]. ADVANCED SCIENCE,2017,4(9).
APA Liu, Wanpeng.,Zhou, Zhitao.,Zhang, Shaoqing.,Shi, Zhifeng.,Tabarini, Justin.,...&Tao, Tiger H..(2017).Precise Protein Photolithography (P-3): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist.ADVANCED SCIENCE,4(9).
MLA Liu, Wanpeng,et al."Precise Protein Photolithography (P-3): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist".ADVANCED SCIENCE 4.9(2017).
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