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Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement | |
2024-11-01 | |
发表期刊 | ADVANCED MATERIALS (IF:27.4[JCR-2023],30.2[5-Year]) |
ISSN | 0935-9648 |
EISSN | 1521-4095 |
发表状态 | 已发表 |
DOI | 10.1002/adma.202409130 |
摘要 | Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-beta plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery. |
关键词 | drug delivery nanofilaments peptides protein adsorptions self-assembly |
URL | 查看原文 |
收录类别 | SCI ; EI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[ |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS记录号 | WOS:001365838400001 |
出版者 | WILEY-V C H VERLAG GMBH |
EI入藏号 | 20244917460072 |
EI主题词 | Hydrogen bonds |
EI分类号 | 102.2.1 ; 103 ; 801.3 Colloid Chemistry |
原始文献类型 | Article in Press |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/458309 |
专题 | 生物医学工程学院 物质科学与技术学院_硕士生 生物医学工程学院_PI研究组_张鹏程组 |
通讯作者 | Zhang, Lu; Zhang, Pengcheng; Li, Yaping |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Yantai Inst Pharmaceut Sci, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China 6.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China 7.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China 8.Chinese Acad Sci, Shanghai Adv Res Inst, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China 9.King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr, Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia 10.King Abdullah Univ Sci & Technol, Comp Sci Program, Comp Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia 11.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China 12.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Biomed Engn, Shanghai 200127, Peoples R China 13.Fujian Prov Key Lab Theoret & Computat Chem, Fujian 361005, Peoples R China |
通讯作者单位 | 生物医学工程学院; 上海科技大学 |
推荐引用方式 GB/T 7714 | Cai, Ying,Xu, Tiantian,Zhu, Binyu,et al. Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement[J]. ADVANCED MATERIALS,2024. |
APA | Cai, Ying.,Xu, Tiantian.,Zhu, Binyu.,Chen, Junfan.,Jiang, Linyang.,...&Li, Yaping.(2024).Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement.ADVANCED MATERIALS. |
MLA | Cai, Ying,et al."Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement".ADVANCED MATERIALS (2024). |
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