Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement
2024-11-01
发表期刊ADVANCED MATERIALS (IF:27.4[JCR-2023],30.2[5-Year])
ISSN0935-9648
EISSN1521-4095
发表状态已发表
DOI10.1002/adma.202409130
摘要

Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-beta plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery.

关键词drug delivery nanofilaments peptides protein adsorptions self-assembly
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收录类别SCI ; EI
语种英语
资助项目National Natural Science Foundation of China[
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:001365838400001
出版者WILEY-V C H VERLAG GMBH
EI入藏号20244917460072
EI主题词Hydrogen bonds
EI分类号102.2.1 ; 103 ; 801.3 Colloid Chemistry
原始文献类型Article in Press
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/458309
专题生物医学工程学院
物质科学与技术学院_硕士生
生物医学工程学院_PI研究组_张鹏程组
通讯作者Zhang, Lu; Zhang, Pengcheng; Li, Yaping
作者单位
1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Pharmaceut Sci, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China
6.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China
7.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China
8.Chinese Acad Sci, Shanghai Adv Res Inst, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China
9.King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr, Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia
10.King Abdullah Univ Sci & Technol, Comp Sci Program, Comp Elect & Math Sci & Engn Div, Thuwal 23955, Saudi Arabia
11.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China
12.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Stem Cell Res Ctr, Dept Urol,Ren Ji Hosp,Sch Biomed Engn, Shanghai 200127, Peoples R China
13.Fujian Prov Key Lab Theoret & Computat Chem, Fujian 361005, Peoples R China
通讯作者单位生物医学工程学院;  上海科技大学
推荐引用方式
GB/T 7714
Cai, Ying,Xu, Tiantian,Zhu, Binyu,et al. Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement[J]. ADVANCED MATERIALS,2024.
APA Cai, Ying.,Xu, Tiantian.,Zhu, Binyu.,Chen, Junfan.,Jiang, Linyang.,...&Li, Yaping.(2024).Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement.ADVANCED MATERIALS.
MLA Cai, Ying,et al."Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement".ADVANCED MATERIALS (2024).
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