A subcortical excitatory circuit for sensory-triggered predatory hunting in mice

doi:10.1038/s41593-019-0405-4

	A subcortical excitatory circuit for sensory-triggered predatory hunting in mice
	Shang, Congping 1,2; Liu, Aixue 2,3; Li, Dapeng 2; Xie, Zhiyong 2; Chen, Zijun 4,5; Huang, Meizhu 2; Li, Yang 2; Wang, Yi 4; Shen, Wei L.6 ; Cao, Peng 2,3
	2019-06
发表期刊	NATURE NEUROSCIENCE (IF:21.2[JCR-2023],25.6[5-Year])
ISSN	1097-6256
卷号	22 期号:6 页码:909-+
发表状态	已发表
DOI	10.1038/s41593-019-0405-4
摘要	Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. The superior colliculus neurons that form this pathway integrate motion-related visual and vibrissal somatosensory cues of prey. During hunting, these neurons send out neural signals that are temporally correlated with predatory attacks, but not with feeding after prey capture. Synaptic inactivation of this pathway selectively blocks hunting for prey without impairing other sensory-triggered behaviors. These data reveal a subcortical neural circuit that is specifically engaged in translating sensory cues into neural signals to provoke predatory hunting.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31671095] ; National Natural Science Foundation of China[31422026] ; National Natural Science Foundation of China[81471311] ; National Natural Science Foundation of China[31771150] ; National Natural Science Foundation of China[91632301]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000468883100010
出版者	NATURE PUBLISHING GROUP
WOS关键词	SUPERIOR COLLICULUS ; PREY CAPTURE ; GABAERGIC NEURONS ; RESPONSES ; BEHAVIOR ; SENSATION ; NUCLEUS ; INPUTS ; RAT
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/45631
专题	生命科学与技术学院_PI研究组_沈伟组
通讯作者	Cao, Peng
作者单位	1.Tsinghua Univ, Sch Life Sci, Peking Univ Tsinghua Univ NIBS Joint Grad Program, Beijing, Peoples R China 2.Natl Inst Biol Sci, Beijing, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Shang, Congping,Liu, Aixue,Li, Dapeng,et al. A subcortical excitatory circuit for sensory-triggered predatory hunting in mice[J]. NATURE NEUROSCIENCE,2019,22(6):909-+.
APA	Shang, Congping.,Liu, Aixue.,Li, Dapeng.,Xie, Zhiyong.,Chen, Zijun.,...&Cao, Peng.(2019).A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.NATURE NEUROSCIENCE,22(6),909-+.
MLA	Shang, Congping,et al."A subcortical excitatory circuit for sensory-triggered predatory hunting in mice".NATURE NEUROSCIENCE 22.6(2019):909-+.