DNA Nanotechnology-Enabled Drug Delivery Systems

doi:10.1021/acs.chemrev.7b00663

	DNA Nanotechnology-Enabled Drug Delivery Systems
	Hu, Qinqin 1,2,3; Li, Hua 4,5; Wang, Lihua6,7,8 ; Gu, Hongzhou 1,2,3,4; Fan, Chunhai6,7,8
	2019-05-22
发表期刊	CHEMICAL REVIEWS (IF:51.4[JCR-2023],63.5[5-Year])
ISSN	0009-2665
EISSN	1520-6890
卷号	119 期号:10 页码:6459-6506
发表状态	已发表
DOI	10.1021/acs.chemrev.7b00663
摘要	Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nano medicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered by DNA nanovehicles. Further, we discuss the cellular fates of DNA nanostructures as well as challenges and opportunities for DNA nanostructure-based drug delivery.
关键词	Bioimaging Controlled drug delivery DNA Medical nanotechnology Surface chemistry Targeted drug delivery Bio-imaging Biodetection Design technique DNA nanostructures DNA nanotechnology Drug-delivery systems Drug-targeting High potential Self-assembly of nanostructures Simple++
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH031]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000469288500007
出版者	AMER CHEMICAL SOC
EI入藏号	20243016766553
EI主题词	Oligonucleotides
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 746 Imaging Techniques ; 761 Nanotechnology ; 801.4 Physical Chemistry
WOS关键词	BLOOD-BRAIN-BARRIER ; SINGLE-STRANDED-DNA ; RECEPTOR-MEDIATED ENDOCYTOSIS ; MESSENGER-RNA DETECTION ; NUCLEIC-ACID JUNCTIONS ; GOLD NANOPARTICLES ; ORIGAMI NANOSTRUCTURES ; INTRACELLULAR DELIVERY ; CELLULAR UPTAKE ; CO-DELIVERY
原始文献类型	Review
引用统计	被引频次：843[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/45614
专题	通识教学中心_外聘教师生命科学与技术学院_特聘教授组_樊春海组
通讯作者	Gu, Hongzhou; Fan, Chunhai
作者单位	1.Fudan Univ, Fudan Univ Shanghai Canc Ctr, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China 3.Fudan Univ, Sch Basic Med Sci, Dept Syst Biol Med, Shanghai 200032, Peoples R China 4.Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China 5.Shandong Buchang Pharmaceut Co Ltd, Res & Dev Ctr, Heze 274000, Peoples R China 6.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 7.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hu, Qinqin,Li, Hua,Wang, Lihua,et al. DNA Nanotechnology-Enabled Drug Delivery Systems[J]. CHEMICAL REVIEWS,2019,119(10):6459-6506.
APA	Hu, Qinqin,Li, Hua,Wang, Lihua,Gu, Hongzhou,&Fan, Chunhai.(2019).DNA Nanotechnology-Enabled Drug Delivery Systems.CHEMICAL REVIEWS,119(10),6459-6506.
MLA	Hu, Qinqin,et al."DNA Nanotechnology-Enabled Drug Delivery Systems".CHEMICAL REVIEWS 119.10(2019):6459-6506.