Inherent symmetry and flexibility in hepatitis B virus subviral particles

doi:DOI: 10.1126/science.adp1453

KMS > 免疫化学研究所

	Inherent symmetry and flexibility in hepatitis B virus subviral particles
	Wang, Quan1,2,3 ; Wang, Tao 4; Cao, Lin 5; Mu, An 6,7; Fu, Sheng 6; Wang, Peipei1 ; Gao, Yan1 ; Ji, Wenxin 3; Liu, Zhenyu 4; Du, Zhanqiang 5; Guddat, Luke W.8; Zhang, Wenchi 6; Li, Shuang 6; Li, Xuemei 6; Lou, Zhiyong 4; Wang, Xiangxi 6; Hu, Zhongyu 9; Rao, Zihe1,4,5,6
	2024-09-12
发表期刊	SCIENCE (IF:44.7[JCR-2023],50.3[5-Year])
ISSN	0036-8075
EISSN	1095-9203
卷号	385 期号:6714
发表状态	已发表
DOI	DOI: 10.1126/science.adp1453
摘要	Chronic hepatitis B virus (HBV) infection poses a major global health challenge with massive morbidity and mortality. Despite a preventive vaccine, current treatments provide limited virus clearance, necessitating lifelong commitment. The HBV surface antigen (HBsAg) is crucial for diagnosis and prognosis, yet its high-resolution structure and assembly on the virus envelope remain elusive. Utilizing extensive datasets and advanced cryo-electron microscopy analysis, we present structural insights into HBsAg at a near-atomic resolution of 3.7 angstroms. HBsAg homodimers assemble into subviral particles with D-2- and D-4-like quasisymmetry, elucidating the dense-packing rules and structural adaptability of HBsAg. These findings provide insights into how HBsAg assembles into higher-order filaments and interacts with the capsid to form virions.
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences grants["XDB08020200","XDB37020203"] ; Science and Technology Commission of Shanghai Municipality grant[YDZX20203100001571] ; National Program on Key Research Project of China["2017YFC0840300","2020YFA0707500"] ; National Natural Science Foundation of China["81520108019","813300237","31971118"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001408428800032
出版者	AMER ASSOC ADVANCEMENT SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/452339
专题	免疫化学研究所免疫化学研究所_特聘教授组_饶子和组生命科学与技术学院_博士生免疫化学研究所_PI研究组_王权组
通讯作者	Wang, Quan; Hu, Zhongyu; Rao, Zihe
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies & Sch Life S, Shanghai, Peoples R China 2.Shanghai Clin Res & Trial Ctr, Shanghai, Peoples R China 3.Shanghai Adv Res Inst, Chinese Acad Sci CAS, Natl Facil Prot Sci, Shanghai, Peoples R China 4.Tsinghua Univ, Struct Biol Lab, Beijing, Peoples R China 5.Nankai Univ, Coll Life Sci, Frontiers Sci Ctr Cell Response, State Key Lab Med Chem Biol, Tianjin, Peoples R China 6.Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, CAS, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia 9.Natl Inst Food & Drug Control, Beijing, Peoples R China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Wang, Quan,Wang, Tao,Cao, Lin,et al. Inherent symmetry and flexibility in hepatitis B virus subviral particles[J]. SCIENCE,2024,385(6714).
APA	Wang, Quan.,Wang, Tao.,Cao, Lin.,Mu, An.,Fu, Sheng.,...&Rao, Zihe.(2024).Inherent symmetry and flexibility in hepatitis B virus subviral particles.SCIENCE,385(6714).
MLA	Wang, Quan,et al."Inherent symmetry and flexibility in hepatitis B virus subviral particles".SCIENCE 385.6714(2024).