Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis

doi:10.1038/s41598-017-10891-0

	Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis
	Zheng, Chao 1,2,3,4,5; Wang, Yuetong 1,2,3; Yang, Liu 1,2,3; Zhou, Shuhua 2; Gao, Yijun 1,2,3; Li, Fuming 1,2,3; Feng, Yan 1,2,3; Wang, Zuoyun 1,2,3; Zhan, Lixing 6; Yan, Qin 7; Zhu, Xueliang 1,2,3; Wong, Kwok-Kin 8,9; Chen, Zhengjun1,2,3 ; Ji, Hongbin1,2,3,10
	2017-09-04
发表期刊	SCIENTIFIC REPORTS (IF:3.8[JCR-2023],4.3[5-Year])
ISSN	2045-2322
卷号	7
发表状态	已发表
DOI	10.1038/s41598-017-10891-0
摘要	Cell division cycle 42 (CDC42) plays important roles in polarity establishment and maintenance as well as cell cycle progression and cell division. Although disruption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumorigenesis are still poorly understood. Here we find that Cdc42 deficiency inhibits the KrasG12D-induced lung alveoli tumor formation, while conversely promotes bronchiole tumor formation in mice. Bronchial Cdc42 loss destroys contact inhibition potentially through cell polarity disruption, and results in increased tumor formation. In contrast, deletion of Cdc42 in alveoli cells prevents KrasG12D-induced cell proliferation, which leads to reduced tumor formation. Further analyses of clinical specimens uncover a significant positive correlation between CDC42 and type II alveolar epithelial cells marker SP-A, indicating the potential importance of CDC42 in this specific subset of lung cancer. Collectively, we identify the lineage-specific function of CDC42 in lung tumorigenesis potentially through the regulation of cell polarity integrity.
收录类别	SCI
语种	英语
资助项目	Shanghai Institutes for Biological Sciences[2014KIP304]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000408997700106
出版者	NATURE PUBLISHING GROUP
WOS关键词	EPITHELIAL-CELL ; RHO-GTPASES ; TUMOR-SUPPRESSOR ; POLARITY PROTEIN ; BREAST-TUMORS ; CDC42 GTPASES ; CANCER-CELLS ; BETA-CATENIN ; E-CADHERIN ; EXPRESSION
原始文献类型	Article
通讯作者	Chen, Zhengjun
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4503
专题	生命科学与技术学院_特聘教授组_陈正军组生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Chen, Zhengjun
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Natl Ctr Prot Sci Shanghai, Shanghai 200031, Peoples R China 5.Chinese Acad Sci, Shanghai Sci Res Ctr, Shanghai 201204, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 7.Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA 8.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA 9.Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02115 USA 10.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Chao,Wang, Yuetong,Yang, Liu,et al. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis[J]. SCIENTIFIC REPORTS,2017,7.
APA	Zheng, Chao.,Wang, Yuetong.,Yang, Liu.,Zhou, Shuhua.,Gao, Yijun.,...&Ji, Hongbin.(2017).Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.SCIENTIFIC REPORTS,7.
MLA	Zheng, Chao,et al."Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis".SCIENTIFIC REPORTS 7(2017).