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| Intra-hypothalamic circuit orchestrates β-endorphin release following coital ejaculation in male mice | |
| 2024-09-19 | |
| 状态 | 已发表 |
| 摘要 | Survey-based evidence suggests that men experience a distinct post-ejaculation affective state1,2, marked by intense pleasure sometimes compared to the euphoric rush from intravenous injection of opioid drugs such as heroin3. However, the intrinsic neural circuit mechanisms underlying the ejaculation-triggered affective state remain unclear. Here, we discovered that Calbindin1-expressing (Calb1+) neurons in the preoptic area (POA) of the hypothalamus, an evolutionarily conserved regulatory region for male mating behavior4, are specifically activated during ejaculation in male mice. Inhibiting POA Calb1+ neurons prolongs mating and delays ejaculation. Importantly, POA Calb1+ neurons transmit the ejaculation signal and activate proopiomelanocortin-expressing (Pomc+) neurons in the arcuate nucleus of the hypothalamus, which show robust and sustained activity lasting for tens of seconds, specifically upon ejaculation. This activity is accompanied by elevated levels of {beta}-endorphins5, opioid peptides secreted by Pomc+ neurons, post-ejaculation in male mice. Optogenetic activation of Pomc+ neurons increases {beta}-endorphins levels and conditioned placed preference, similar to ejaculation. Conversely, intracerebroventricular (i.c.v.) infusion of drugs blocking Pomc neuropeptides signaling eliminates ejaculation-conditioned place preference. Collectively, these results elucidate an intra-hypothalamic circuit from POA Calb1+ neurons to arcuate Pomc+ neurons that coordinate β-endorphin release with ejaculation, shedding light on the neurobiological basis of the post-ejaculation affective state. |
| 语种 | 英语 |
| DOI | 10.1101/2024.09.18.613624 |
| 相关网址 | 查看原文 |
| 出处 | bioRxiv |
| 收录类别 | PPRN.PPRN |
| WOS记录号 | PPRN:91948542 |
| WOS类目 | Neurosciences |
| 文献类型 | 预印本 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/430449 |
| 专题 | 生命科学与技术学院 生命科学与技术学院_博士生 |
| 通讯作者 | Xu, Xiao-Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intelligence Technol, Shanghai 200031, Peoples R China 4.Lingang Lab, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Chinese Acad Sci, Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundamental Res Inst, Brain Cognit & Brain Dis Inst BCBDI, Shenzhen Inst Adv Technol,Guangdong Prov Key Lab Brain Connectome & Behav,CAS Key Lab Brain Connectome & Manipulat, Shenzhen, Peoples R China 7.Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109, USA |
| 推荐引用方式 GB/T 7714 | Zha, Xi,Jiao, Zhuo-Lei,Li, Shuai-Shuai,et al. Intra-hypothalamic circuit orchestrates β-endorphin release following coital ejaculation in male mice. 2024. |
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