Free-breathing non-contrast T1Ï dispersion magnetic resonance imaging of myocardial interstitial fibrosis in comparison with extracellular volume fraction

doi:10.1016/j.jocmr.2024.101093

	Free-breathing non-contrast T1Ï dispersion magnetic resonance imaging of myocardial interstitial fibrosis in comparison with extracellular volume fraction
	Miao, Qinfang1,2 ; Hua, Sha 3; Gong, Yiwen 3; Lyu, Zhenfeng1,2 ; Qian, Pengfang1,2 ; Liu, Chun1,2 ; Jin, Wei 3; Hu, Peng1,2 ; Qi, Haikun1,2
发表期刊	JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE (IF:4.2[JCR-2023],5.5[5-Year])
ISSN	1097-6647
EISSN	1532-429X
卷号	26 期号:2
发表状态	已发表
DOI	10.1016/j.jocmr.2024.101093
摘要	Background: Myocardial fibrosis is a common feature in various cardiac diseases. It causes adverse cardiac remodeling and is associated with poor clinical outcomes. Late gadolinium enhancement (LGE) and extracellular volume fraction (ECV) are the standard magnetic resonance imaging techniques for detecting focal and diffuse myocardial fibrosis. However, these contrast-enhanced techniques require the administration of gadolinium contrast agents, which is not applicable to patients with gadolinium contraindications. To eliminate the need for contrast agents, we developed and applied an endogenous free-breathing T1 rho dispersion imaging technique (FBMultiMap) for diagnosing diffuse myocardial fibrosis in a cohort with suspected cardiomyopathies. Methods: The proposed FB-MultiMap technique, enabling T2, T1 rho, and their difference (myocardial fibrosis index [mFI]) quantification in a single scan was developed in phantoms and 15 healthy subjects. In the clinical study, 55 patients with suspected cardiomyopathies were imaged using FB-MultiMap, conventional native T1 mapping, LGE, and ECV imaging. The accuracy of the endogenous parameters for predicting increased ECV was evaluated using receiver operating characteristic curve analysis. In addition, the correlation of native T1, T1 rho, and mFI with ECV was, respectively, assessed using Pearson correlation coefficients. Results: FB-MultiMap showed a good agreement with conventional separate breath-hold mapping techniques in phantoms and healthy subjects. Considering all the patients, T1 rho was more accurate than mFI and native T1 for predicting increased ECV, with area under the curve (AUC) values of 0.91, 0.79, and 0.75, respectively, and showed a stronger correlation with ECV (correlation coefficient r: 0.72 vs 0.52 vs 0.40). In the subset of 47 patients with normal T2 values, the diagnostic performance of mFI was significantly strengthened (AUC = 0.90, r = 0.83), outperforming T1 rho and native T1. Conclusion: The proposed free-breathing T1 rho dispersion imaging technique enabling simultaneous quantification of T2, T1 rho, and mFI in a single scan has shown great potential for diagnosing diffuse myocardial fibrosis in patients with complex cardiomyopathies without contrast agents.
关键词	T1 rho mapping T1 rho dispersion imaging Non-contrast cardiac MR Myocardial fibrosis
URL	查看原文
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82102027] ; Explorer Program of Shanghai Municipality[23TS1400300] ; Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine[JYJC202134]
WOS研究方向	Cardiovascular System & Cardiology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Cardiac & Cardiovascular Systems ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001359935900001
出版者	ELSEVIER SCIENCE INC
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/424464
专题	信息科学与技术学院_博士生信息科学与技术学院_硕士生生物医学工程学院_PI研究组_齐海坤组生物医学工程学院_PI研究组_胡鹏组
共同第一作者	Hua, Sha
通讯作者	Qi, Haikun
作者单位	1.School of Biomedical Engineering, ShanghaiTech University, 4th Floor, BME Building, 393 Middle Huaxia Road, Pudong District, Shanghai 201210, China 2.Shanghai Clinical Research and Trial Center, Shanghai, China 3.Department of Cardiovascular Medicine, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China
第一作者单位	生物医学工程学院
通讯作者单位	生物医学工程学院
第一作者的第一单位	生物医学工程学院
推荐引用方式 GB/T 7714	Miao, Qinfang,Hua, Sha,Gong, Yiwen,et al. Free-breathing non-contrast T1Ï dispersion magnetic resonance imaging of myocardial interstitial fibrosis in comparison with extracellular volume fraction[J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE,26(2).
APA	Miao, Qinfang.,Hua, Sha.,Gong, Yiwen.,Lyu, Zhenfeng.,Qian, Pengfang.,...&Qi, Haikun.
MLA	Miao, Qinfang,et al."Free-breathing non-contrast T1Ï dispersion magnetic resonance imaging of myocardial interstitial fibrosis in comparison with extracellular volume fraction".JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE 26.2