上海科技大学知识管理系统

["Catalytic multicomponent reactions offer an efficient synthetic approach for constructing multiple chemical bonds in a single step. However, the carboamination of unactivated alkenes, involving nitrogen radical species directly from N-H precursors, is infrequent due to the high bond energy and challenges in step matching. Herein we demonstrate a catalytic radical three-component reaction using simple primary sulfonamides, which provides a novel method for constructing a library of complex architectures through carbon-nitrogen and carbon-carbon bond formation. The newly developed method demonstrates a high degree of tolerance towards various functional groups, proving to be highly efficient in the late-stage modification of complex drug molecules and natural products under very mild conditions.","We demonstrate a catalytic radical three-component reaction using primary sulfonamides as N-H precursors, which provides a novel method for constructing a library of complex architectures through carbon-nitrogen and carbon-carbon bond formation."]