Non-Equilibrium Dissipative Assembly with Switchable Biological Functions

doi:10.1002/anie.202409169

	Non-Equilibrium Dissipative Assembly with Switchable Biological Functions
	Zhao P(赵鹏)1 ; Zhao YF(赵远峰)1 ; Lu Y(卢彦)1 ; Xu LJ(徐林洁)1 ; Li BH(李博涵)1 ; Zhao YS(赵英帅)1 ; Zhou W(周维)1 ; Pu Yan1 ; Wang YF(王友付)2; Cao KC(曹克诚)1 ; Zheng YJ(郑宜君)1
	2024-10-01
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN	1433-7851
EISSN	1521-3773
发表状态	已发表
DOI	10.1002/anie.202409169
摘要	["Natural dissipative assembly (DSA) often exhibit energy-driven shifts in natural functions. However, creating man-made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane-like dissipative assembly system based on chiral supramolecules. This system employs benzoyl cysteine in an out of equilibrium manner, enabling the shifts in biofunctions while minimizing material use. Specifically, aroyl-cystine derivatives primarily assemble into stable M-helix nanofibers under equilibrium conditions. These nanofibers enhance fibroblast adhesion and proliferation through stereospecific interactions with chiral cellular membranes. Upon the addition of chemical fuels, these functional nanofibers temporarily transform into non-equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, these nanospheres revert to their original nanofiber state, effectively recycling the drug. The programmable function-shifting ability of this DSA establishes it as a novel, fuel-driven drug delivery vehicle. And the bioactive DSA not only addresses a gap in synthetic DSAs within biological applications but also sets the stage for innovative designs of ' living ' materials.","A switchable non-equilibrium dissipative assembly promoting fibroblast adhesion/proliferation and efficient drug delivery was developed using chemical fuel. Nanofibers acted as chiral hydrogel scaffolds for cell adhesion and drug reservoirs. This system transitions between nanofiber and nanospherical forms, enabling targeted drug delivery and recovery, highlighting its scientific significance. image"]
关键词	Dissipative self-assembly out of equilibrium systems chiral supramolecules fuel-driven drug delivery nanofiber-nanosphere transition
URL	查看原文
收录类别	SCIE ; EI ; SCI
语种	英语
资助项目	National Natural Science Foundation of Shanghai[23ZR1442700] ; Analytical Instrumentation Center[SPST-AIC10112914] ; null[52073175] ; null[22107064]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:001335865900001
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20244217224414
EI主题词	Nanospheres
EI分类号	101.3 ; 101.7 ; 102.2 ; 102.2.1 ; 103 ; 1301.4 ; 203 ; 761 Nanotechnology
原始文献类型	Article in Press
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/414274
专题	物质科学与技术学院_PI研究组_郑宜君组生命科学与技术学院_硕士生物质科学与技术学院_硕士生物质科学与技术学院_博士生物质科学与技术学院_PI研究组_曹克诚组
共同第一作者	Zhao YF(赵远峰)
通讯作者	Zheng YJ(郑宜君)
作者单位	1.上海科技大学 2.上海交通大学
第一作者单位	上海科技大学
通讯作者单位	上海科技大学
第一作者的第一单位	上海科技大学
推荐引用方式 GB/T 7714	Zhao P,Zhao YF,Lu Y,et al. Non-Equilibrium Dissipative Assembly with Switchable Biological Functions[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2024.
APA	Zhao P.,Zhao YF.,Lu Y.,Xu LJ.,Li BH.,...&Zheng YJ.(2024).Non-Equilibrium Dissipative Assembly with Switchable Biological Functions.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Zhao P,et al."Non-Equilibrium Dissipative Assembly with Switchable Biological Functions".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2024).