The <i>kpc-1</i> 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship

doi:10.1371/journal.pgen.1011362

	*The kpc-1* 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship**
	Shih, Mushaine1 ; Zou, Yan1,2 ; Ferreira, Tarsis 3; Suzuki, Nobuko 1; Kim, Eunseo 1; Chuang, Chiou-Fen 1; Chang, Chieh 1
	2024-08-01
发表期刊	PLOS GENETICS (IF:4.0[JCR-2023],4.9[5-Year])
ISSN	1553-7404
卷号	20 期号:8
发表状态	已发表
DOI	10.1371/journal.pgen.1011362
摘要	A recently reported Schizophrenia-associated genetic variant in the 3 ' UTR of the human furin gene, a homolog of C. elegans kpc-1, highlights an important role of the furin 3 ' UTR in neuronal development. We isolate three kpc-1 mutants that display abnormal dendrite arborization in PVD neurons and defective male mating behaviors. We show that the kpc-1 3 ' UTR participates in dendrite branching and self-avoidance. The kpc-1 3 ' UTR facilitates mRNA localization to branching points and contact points between sibling dendrites and promotes translation efficiency. A predicted secondary structural motif in the kpc-1 3 ' UTR is required for dendrite self-avoidance. Animals with over-expression of DMA-1, a PVD dendrite receptor, exhibit similar dendrite branching and self-avoidance defects that are suppressed with kpc-1 over-expression. Our results support a model in which KPC-1 proteins are synthesized at branching points and contact points to locally down-regulate DMA-1 receptors to promote dendrite branching and self-avoidance of a mechanosensory neuron important for male courtship.
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收录类别	SCI
语种	英语
资助项目	National Science Foundation[IOS-1455758] ; National Institute of General Medical Sciences of the National Institutes of Health[R01GM111320]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:001288641000001
出版者	PUBLIC LIBRARY SCIENCE
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/414156
专题	生命科学与技术学院生命科学与技术学院_PI研究组_邹燕组
通讯作者	Chang, Chieh
作者单位	1.Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Cincinnati Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH USA
推荐引用方式 GB/T 7714	Shih, Mushaine,Zou, Yan,Ferreira, Tarsis,et al. The kpc-1 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship[J]. PLOS GENETICS,2024,20(8).
APA	Shih, Mushaine.,Zou, Yan.,Ferreira, Tarsis.,Suzuki, Nobuko.,Kim, Eunseo.,...&Chang, Chieh.(2024).The kpc-1 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLOS GENETICS,20(8).
MLA	Shih, Mushaine,et al."The kpc-1 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship".PLOS GENETICS 20.8(2024).