Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis
Zhang, Ying-Ying1; Wang, Kai1; Liu, Yun-E1; Wang, Wei2; Liu, Ao-Fei1; Zhou, Ji1; Li, Chen1; Zhang, Yi-Qun1; Zhang, Ai-Ping1; Lv, Jin1,3; Jiang, Wei-Jian1
2019-06
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN1107-3756
Volume43Issue:6Pages:2429-2439
Status已发表
DOI10.3892/ijmm.2019.4159
AbstractCerebral ischemia-reperfusion injury (CIRI) usually causes detrimental complications following reperfusion therapy in stroke patients. The present study systematically investigated the regulatory mechanism involved in the pathogenesis of CIRI using gene set enrichment analysis of the transient middle cerebral artery occlusion mouse stroke model. The results revealed a total of 13 CIRI-related transcription factors (TFs), including CCAAT enhancer binding protein b (Cebpb), Cebpa, early growth response-1, Fos, Rela, Jund, signal transduction and activator of transcription 5a/b, transformation related protein 53, GLI family zinc finger 2 (Gli2), Sp3, TF AP-2 (Tfap2a) and spleen focus forming virus proviral integration oncogene (Spi1). To the best of our knowledge, five TFs (Cebpa, Gli2, Sp3, Tfap2a and Spi1) were the first to be reported associated with CIRI in the present study. The five novel CIRI-related TFs were mainly associated with pathways of inflammation and responses to reperfusion, including the tumor necrosis factor signaling pathway (Gli2, Spi1 and Tfap2a, P=0.0035, 0.0035 and 0.048, respectively), interleuking-17 signaling pathway (Cebpa, Gli2, Sp3, Spi1 and Tfap2a, P=0.019, 0.047, 0.019, 0.035 and 0.005, respectively) and fluid shear stress and atherosclerosis (Gli2, Sp3, Spi1 and Tfap2a, P=0.047, 0.046, 0.013 and 0.003, respectively). These results may improve understanding of the potential molecular mechanism underlying the pathogenesis of CIRI at the genome-wide level.
Keywordischemic stroke cerebral ischemia-reperfusion injury transcription factor gene-set enrichment analysis functional pathway enrichment
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81471767] ; National Natural Science Foundation of China[81871464]
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000467649900015
PublisherSPANDIDOS PUBL LTD
WOS KeywordNF-KAPPA-B ; SIGNALING PATHWAY ; ARTERY OCCLUSION ; BRAIN ISCHEMIA ; C/EBP-ALPHA ; EXPRESSION ; ACTIVATION ; DAMAGE ; CONTRIBUTES ; PROTECTS
Original Document TypeArticle
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/40839
Collection免疫化学研究所_公共科研平台_生物医学大数据平台
Corresponding AuthorLv, Jin; Jiang, Wei-Jian
Affiliation1.PLA Rocket Force Characterist Med Ctr, New Era Stroke Care & Res Inst, Dept Vasc Neurosurg, 16 Xin Wai Ave, Beijing 100088, Peoples R China
2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
3.PLA Rocket Force Characterist Med Ctr, Dept Nucl & Radiat Injury, Beijing 100088, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ying-Ying,Wang, Kai,Liu, Yun-E,et al. Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2019,43(6):2429-2439.
APA Zhang, Ying-Ying.,Wang, Kai.,Liu, Yun-E.,Wang, Wei.,Liu, Ao-Fei.,...&Jiang, Wei-Jian.(2019).Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,43(6),2429-2439.
MLA Zhang, Ying-Ying,et al."Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 43.6(2019):2429-2439.
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