Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis

doi:10.3892/ijmm.2019.4159

	Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis
	Zhang, Ying-Ying 1; Wang, Kai 1; Liu, Yun-E 1; Wang, Wei2 ; Liu, Ao-Fei 1; Zhou, Ji 1; Li, Chen 1; Zhang, Yi-Qun 1; Zhang, Ai-Ping 1; Lv, Jin 1,3; Jiang, Wei-Jian 1
	2019-06
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN	1107-3756
卷号	43 期号:6 页码:2429-2439
发表状态	已发表
DOI	10.3892/ijmm.2019.4159
摘要	Cerebral ischemia-reperfusion injury (CIRI) usually causes detrimental complications following reperfusion therapy in stroke patients. The present study systematically investigated the regulatory mechanism involved in the pathogenesis of CIRI using gene set enrichment analysis of the transient middle cerebral artery occlusion mouse stroke model. The results revealed a total of 13 CIRI-related transcription factors (TFs), including CCAAT enhancer binding protein b (Cebpb), Cebpa, early growth response-1, Fos, Rela, Jund, signal transduction and activator of transcription 5a/b, transformation related protein 53, GLI family zinc finger 2 (Gli2), Sp3, TF AP-2 (Tfap2a) and spleen focus forming virus proviral integration oncogene (Spi1). To the best of our knowledge, five TFs (Cebpa, Gli2, Sp3, Tfap2a and Spi1) were the first to be reported associated with CIRI in the present study. The five novel CIRI-related TFs were mainly associated with pathways of inflammation and responses to reperfusion, including the tumor necrosis factor signaling pathway (Gli2, Spi1 and Tfap2a, P=0.0035, 0.0035 and 0.048, respectively), interleuking-17 signaling pathway (Cebpa, Gli2, Sp3, Spi1 and Tfap2a, P=0.019, 0.047, 0.019, 0.035 and 0.005, respectively) and fluid shear stress and atherosclerosis (Gli2, Sp3, Spi1 and Tfap2a, P=0.047, 0.046, 0.013 and 0.003, respectively). These results may improve understanding of the potential molecular mechanism underlying the pathogenesis of CIRI at the genome-wide level.
关键词	ischemic stroke cerebral ischemia-reperfusion injury transcription factor gene-set enrichment analysis functional pathway enrichment
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81471767] ; National Natural Science Foundation of China[81871464]
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000467649900015
出版者	SPANDIDOS PUBL LTD
WOS关键词	NF-KAPPA-B ; SIGNALING PATHWAY ; ARTERY OCCLUSION ; BRAIN ISCHEMIA ; C/EBP-ALPHA ; EXPRESSION ; ACTIVATION ; DAMAGE ; CONTRIBUTES ; PROTECTS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/40839
专题	免疫化学研究所_公共科研平台_生物医学大数据平台
通讯作者	Lv, Jin; Jiang, Wei-Jian
作者单位	1.PLA Rocket Force Characterist Med Ctr, New Era Stroke Care & Res Inst, Dept Vasc Neurosurg, 16 Xin Wai Ave, Beijing 100088, Peoples R China 2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 3.PLA Rocket Force Characterist Med Ctr, Dept Nucl & Radiat Injury, Beijing 100088, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying-Ying,Wang, Kai,Liu, Yun-E,et al. Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2019,43(6):2429-2439.
APA	Zhang, Ying-Ying.,Wang, Kai.,Liu, Yun-E.,Wang, Wei.,Liu, Ao-Fei.,...&Jiang, Wei-Jian.(2019).Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,43(6),2429-2439.
MLA	Zhang, Ying-Ying,et al."Identification of key transcription factors associated with cerebral ischemia-reperfusion injury based on gene-set enrichment analysis".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 43.6(2019):2429-2439.