The onset mechanism of Parkinson's beta oscillations: A theoretical analysis

doi:10.1016/j.jtbi.2019.03.008

	The onset mechanism of Parkinson's beta oscillations: A theoretical analysis
	Hu, Bing 1,2; Diao, Xiyezi 3; Zong, Liqing 3; Zhang, Jingsong 2; Yu, Liang 2; Dai, Hao 2; Chen, Luonan2,4,5,6
	2019-06-07
发表期刊	JOURNAL OF THEORETICAL BIOLOGY (IF:1.9[JCR-2023],1.9[5-Year])
ISSN	0022-5193
卷号	470 页码:1-16
发表状态	已发表
DOI	10.1016/j.jtbi.2019.03.008
摘要	In this paper, we build a basal ganglia-cortex-thalamus model to study the oscillatory mechanisms and boundary conditions of the beta frequency band (13-30 Hz) that appears in the subthalamic nucleus. First, a theoretical oscillatory boundary formula is obtained in a simplified model by using the Laplace transform and linearization process of the system at fixed points. Second, we simulate the oscillatory boundary conditions through numerical calculations, which fit with our theoretical results very well, at least in the changing trend. We find that several critical coupling strengths in the model exert great effects on the oscillations, the mechanisms of which differ but can be explained in detail by our model and the oscillatory boundary formula. Specifically, we note that the relatively small or large sizes of the coupling strength from the fast-spiking interneurons to the medium spiny neurons and from the cortex to the fast-spiking interneurons both have obvious maintenance roles on the states. Similar phenomena have been reported in other neurological diseases, such as absence epilepsy. However, some of those interesting mutual regulation mechanisms in the model have rarely been considered in previous studies. In addition to the coupling weight in the pathway, in this work, we show that the delay is a key parameter that affects oscillations. On the one hand, the system needs a minimum delay to generate oscillations; on the other hand, in the appropriate range, a longer delay leads to a higher activation level of the subthalamic nucleus. In this paper, we study the oscillation activities that appear on the subthalamic nucleus. Moreover, all populations in the model show the dynamic behaviour of a synchronous resonance. Therefore, we infer that the mechanisms obtained can be expanded to explore the state of other populations, and that the model provides a unified framework for studying similar problems in the future. Moreover, the oscillatory boundary curves obtained are all critical conditions between the stable state and beta frequency oscillation. The method is also suitable for depicting other common frequency bands during brain oscillations, such as the alpha band (8-12 Hz), theta band (4-7 Hz) and delta band (1-3 Hz). Thus, the results of this work are expected to help us better understand the onset mechanism of parkinson's oscillations and can inspire related experimental research in this field. (C) 2019 Elsevier Ltd. All rights reserved.
关键词	Beta oscillation Subthalamic nucleus Basal ganglia Mean-field network
收录类别	SCI ; SCIE
语种	英语
资助项目	Scientific and technological innovation fund for college students (SRF) of Huazhong Agricultural University[2018323]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS类目	Biology ; Mathematical & Computational Biology
WOS记录号	WOS:000465366500001
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS关键词	DEEP BRAIN-STIMULATION ; SUBTHALAMIC NUCLEUS ; BASAL GANGLIA ; RESPONSE CHARACTERISTICS ; MEMBRANE-PROPERTIES ; GAMMA OSCILLATIONS ; ACTIVITY PATTERNS ; PREMOTOR CORTEX ; NEURONS ; DISEASE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/40833
专题	生命科学与技术学院_特聘教授组_陈洛南组
通讯作者	Hu, Bing; Chen, Luonan
作者单位	1.Zhejiang Univ Technol, Dept Appl Math, Hangzhou 310023, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol,Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 3.Huazhong Agr Univ, Dept Math & Stat, Coll Sci, Wuhan 430070, Hubei, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 6.Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hu, Bing,Diao, Xiyezi,Zong, Liqing,et al. The onset mechanism of Parkinson's beta oscillations: A theoretical analysis[J]. JOURNAL OF THEORETICAL BIOLOGY,2019,470:1-16.
APA	Hu, Bing.,Diao, Xiyezi.,Zong, Liqing.,Zhang, Jingsong.,Yu, Liang.,...&Chen, Luonan.(2019).The onset mechanism of Parkinson's beta oscillations: A theoretical analysis.JOURNAL OF THEORETICAL BIOLOGY,470,1-16.
MLA	Hu, Bing,et al."The onset mechanism of Parkinson's beta oscillations: A theoretical analysis".JOURNAL OF THEORETICAL BIOLOGY 470(2019):1-16.