Assessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches

doi:10.1186/s13244-024-01736-2

	Assessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches
	Hu, Wentao 1; Dai, Yongming2 ; Liu, Fang 1; Yang, Tianshu 1; Wang, Yao 1; Shen, Yiwei 3; Zhou, Wenyan 3; Wu, Dongmei 4; Gu, Leyi 3; Zhang, Minfang 3; Zhou, Yan 1
	2024-06-20
发表期刊	INSIGHTS INTO IMAGING (IF:4.1[JCR-2023],5.9[5-Year])
ISSN	1869-4101
卷号	15 期号:1
发表状态	已发表
DOI	10.1186/s13244-024-01736-2
摘要	Objective To assess renal interstitial fibrosis (IF) using diffusion MRI approaches, and explore whether corticomedullary difference (CMD) of diffusion parameters, combination among MRI parameters, or combination with estimated glomerular filtration rate (eGFR) benefit IF evaluation. Methods Forty-two patients with chronic kidney disease were included, undergoing MRI examinations. MRI parameters from apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI), and diffusion-relaxation correlated spectrum imaging (DR-CSI) were obtained both for renal cortex and medulla. CMD of these parameters was calculated. Pathological IF scores (1-3) were obtained by biopsy. Patients were divided into mild (IF = 1, n = 23) and moderate-severe fibrosis (IF = 2-3, n = 19) groups. Group comparisons for MRI parameters were performed. Diagnostic performances were assessed by the receiver operator's curve analysis for discriminating mild from moderate-severe IF patients. Results Significant inter-group differences existed for cortical ADC, IVIM-D, IVIM-f, DKI-MD, DR-CSI V-B, and DR-CSI V-C. Significant inter-group differences existed in Delta ADC, Delta MD, Delta V-B, Delta V-C, Delta Q(B,) and Delta Q(C). Among the cortical MRI parameters, V-B displayed the highest AUC = 0.849, while ADC, f, and MD also showed AUC > 0.8. After combining cortical value and CMD, the diagnostic performances of the MRI parameters were slightly improved except for IVIM-D. Combining V-B with f brings the best performance (AUC = 0.903) among MRI bi-variant models. A combination of cortical V-B, Delta ADC, and eGFR brought obvious improvement in diagnostic performance (AUC 0.963 vs 0.879, specificity 0.826 vs 0.896, and sensitivity 1.000 vs 0.842) than eGFR alone. Conclusion Our study shows promising results for the assessment of renal IF using diffusion MRI approaches.
关键词	Renal interstitial fibrosis Diffusion relaxation correlated spectrum imaging Intra-voxel incoherent motion Diffusion kurtosis imaging Corticomedullary difference
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001251872300005
出版者	SPRINGER WIEN
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/395853
专题	生物医学工程学院生物医学工程学院_PI研究组_胡鹏组
通讯作者	Zhang, Minfang; Zhou, Yan
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Radiol, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Nephrol, Shanghai, Peoples R China 4.East China Normal Univ, Sch Phys & Elect Sci, Shanghai Key Lab Magnet Resonance, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Hu, Wentao,Dai, Yongming,Liu, Fang,et al. Assessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches[J]. INSIGHTS INTO IMAGING,2024,15(1).
APA	Hu, Wentao.,Dai, Yongming.,Liu, Fang.,Yang, Tianshu.,Wang, Yao.,...&Zhou, Yan.(2024).Assessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches.INSIGHTS INTO IMAGING,15(1).
MLA	Hu, Wentao,et al."Assessing renal interstitial fibrosis using compartmental, non-compartmental, and model-free diffusion MRI approaches".INSIGHTS INTO IMAGING 15.1(2024).