SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress

doi:10.1038/s42003-024-06232-3

	SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress
	Jing, Shuaiyang1,2 ; Gao, Jingkai1,2 ; Tiwari, Neeraj 3; Du, Yulei1,2 ; Zhu, Lianhui1 ; Gim, Bopil4 ; Qian, Yi1 ; Yue, Xihua1 ; Lee, Intaek1
	2024-05-06
发表期刊	COMMUNICATIONS BIOLOGY (IF:5.2[JCR-2023],5.6[5-Year])
EISSN	2399-3642
卷号	7 期号:1
发表状态	已发表
DOI	10.1038/s42003-024-06232-3
摘要	["Golgin tethers are known to mediate vesicular transport in the secretory pathway, whereas it is relatively unknown whether they may mediate cellular stress response within the cell. Here, we describe a cellular stress response during heat shock stress via SUMOylation of a Golgin tether, Golgin45. We found that Golgin45 is a SUMOylated Golgin via SUMO1 under steady state condition. Upon heat shock stress, the Golgin enters the nucleus by interacting with Importin-beta 2 and gets further modified by SUMO3. Importantly, SUMOylated Golgin45 appears to interact with PML and SUMO-deficient Golgin45 mutant functions as a dominant negative for PML-NB formation during heat shock stress, suppressing transcription of lipid metabolism genes. These results indicate that Golgin45 may play a role in heat stress response by transcriptional regulation of lipid metabolism genes in SUMOylation-dependent fashion.","Golgin45, a Golgi structural protein, is heavily SUMOylated and heat shock stress increases Golgin45 SUMOylation modified by SUMO3 and promotes its inclusion into PML-NBs to transcriptionally regulate lipid metabolism genes."]
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收录类别	SCI
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS类目	Biology ; Multidisciplinary Sciences
WOS记录号	WOS:001214929900001
出版者	NATURE PORTFOLIO
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/387270
专题	生命科学与技术学院物质科学与技术学院生命科学与技术学院_特聘教授组_James E. Rothman组物质科学与技术学院_PI研究组_yongjin lee组生命科学与技术学院_硕士生生命科学与技术学院_博士生
通讯作者	Qian, Yi; Yue, Xihua; Lee, Intaek
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA 4.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Jing, Shuaiyang,Gao, Jingkai,Tiwari, Neeraj,et al. SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress[J]. COMMUNICATIONS BIOLOGY,2024,7(1).
APA	Jing, Shuaiyang.,Gao, Jingkai.,Tiwari, Neeraj.,Du, Yulei.,Zhu, Lianhui.,...&Lee, Intaek.(2024).SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress.COMMUNICATIONS BIOLOGY,7(1).
MLA	Jing, Shuaiyang,et al."SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress".COMMUNICATIONS BIOLOGY 7.1(2024).