From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors

doi:10.1016/j.stem.2024.02.003

	From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors
	Huang, Yuwei1,2 ; Wang, Haopeng1,3,4
	2024-03-07
发表期刊	CELL STEM CELL (IF:19.8[JCR-2023],22.6[5-Year])
ISSN	1934-5909
EISSN	1875-9777
卷号	31 期号:3
发表状态	已发表
DOI	10.1016/j.stem.2024.02.003
摘要	Aiming to improve the effector function of CAR-T cells, Zhao et al. (1) report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:001214990600001
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/375670
专题	生命科学与技术学院生命科学与技术学院_PI研究组_王皞鹏组生命科学与技术学院_博士生
通讯作者	Wang, Haopeng
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Lingang Lab, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai, Peoples R China 4.Shanghai Clin Res & Trial Ctr, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院; 上海科技大学
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Huang, Yuwei,Wang, Haopeng. From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors[J]. CELL STEM CELL,2024,31(3).
APA	Huang, Yuwei,&Wang, Haopeng.(2024).From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors.CELL STEM CELL,31(3).
MLA	Huang, Yuwei,et al."From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors".CELL STEM CELL 31.3(2024).