Conjunctive encoding of exploratory intentions and spatial information in the hippocampus

doi:10.1038/s41467-024-47570-4

KMS > iHuman研究所

	Conjunctive encoding of exploratory intentions and spatial information in the hippocampus
	Zeng, Yi-Fan1,2 ; Yang, Ke-Xin 2; Cui, Yilong1,2 ; Zhu, Xiao-Na2 ; Li, Rui1,2 ; Zhang, Hanqing1 ; Wu, Dong Chuan 3,4; Stevens, Raymond C.1,2 ; Hu, Ji1,2 ; Zhou, Ning1
	2024-04-15
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	15 期号:1
发表状态	已发表
DOI	10.1038/s41467-024-47570-4
摘要	["The hippocampus creates a cognitive map of the external environment by encoding spatial and self-motion-related information. However, it is unclear whether hippocampal neurons could also incorporate internal cognitive states reflecting an animal's exploratory intention, which is not driven by rewards or unexpected sensory stimuli. In this study, a subgroup of CA1 neurons was found to encode both spatial information and animals' investigatory intentions in male mice. These neurons became active before the initiation of exploration behaviors at specific locations and were nearly silent when the same fields were traversed without exploration. Interestingly, this neuronal activity could not be explained by object features, rewards, or mismatches in environmental cues. Inhibition of the lateral entorhinal cortex decreased the activity of these cells during exploration. Our findings demonstrate that hippocampal neurons may bridge external and internal signals, indicating a potential connection between spatial representation and intentional states in the construction of internal navigation systems.","The hippocampus maps space, but its role in encoding investigatory intentions is unclear. Here the authors show that certain CA1 neurons encode both spatial information and animals' intention to explore, depending on input from lateral entorhinal cortex."]
URL	查看原文
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China (National Science Foundation of China)["32170959","2030","2021ZD0203900","MOST110-2320-B-039-010-MY3","MOST111-2321-B-A49-005"] ; ShanghaiTech University, National Science Foundation of China[112-2321-B-A49-009] ; NSTC[CMU109-MF-31]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001205214400001
出版者	NATURE PORTFOLIO
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/372870
专题	iHuman研究所生命科学与技术学院生命科学与技术学院_PI研究组_胡霁组 iHuman研究所_特聘教授组_Raymond Stevens组生命科学与技术学院_硕士生生命科学与技术学院_博士生 iHuman研究所_PI研究组_周宁组
通讯作者	Zhou, Ning
作者单位	1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.China Med Univ, Grad Inst Biomed Sci, Neurosci & Brain Dis Ctr, Taichung 404333, Taiwan 4.China Med Univ Hosp, Translat Med Res Ctr, Taichung 404333, Taiwan
第一作者单位	iHuman研究所; 生命科学与技术学院
通讯作者单位	iHuman研究所
第一作者的第一单位	iHuman研究所
推荐引用方式 GB/T 7714	Zeng, Yi-Fan,Yang, Ke-Xin,Cui, Yilong,et al. Conjunctive encoding of exploratory intentions and spatial information in the hippocampus[J]. NATURE COMMUNICATIONS,2024,15(1).
APA	Zeng, Yi-Fan.,Yang, Ke-Xin.,Cui, Yilong.,Zhu, Xiao-Na.,Li, Rui.,...&Zhou, Ning.(2024).Conjunctive encoding of exploratory intentions and spatial information in the hippocampus.NATURE COMMUNICATIONS,15(1).
MLA	Zeng, Yi-Fan,et al."Conjunctive encoding of exploratory intentions and spatial information in the hippocampus".NATURE COMMUNICATIONS 15.1(2024).