Ultraflexible PEDOT:PSS/IrOx-Modified Electrodes: Applications in Behavioral Modulation and Neural Signal Recording in Mice

doi:10.3390/mi15040447

	Ultraflexible PEDOT:PSS/IrOx-Modified Electrodes: Applications in Behavioral Modulation and Neural Signal Recording in Mice
	Wang, Xueying 1,2; Jiang, Wanqi 1,2; Yang, Huiran 1; Ye, Yifei 1,3; Zhou, Zhitao 1,2; Sun, Liuyang 1,2,3; Nie, Yanyan 4; Tao, Tiger H.1,2,3,5,6,7,8,9,10 ; Wei, Xiaoling 1,2
	2024-04
发表期刊	MICROMACHINES (IF:3.0[JCR-2023],3.0[5-Year])
EISSN	2072-666X
卷号	15 期号:4
发表状态	已发表
DOI	10.3390/mi15040447
摘要	Recent advancements in neural probe technology have become pivotal in both neuroscience research and the clinical management of neurological disorders. State-of-the-art developments have led to the advent of multichannel, high-density bidirectional neural interfaces that are adept at both recording and modulating neuronal activity within the central nervous system. Despite this progress, extant bidirectional probes designed for simultaneous recording and stimulation are beset with limitations, including elicitation of inflammatory responses and insufficient charge injection capacity. In this paper, we delineate the design and application of an innovative ultraflexible bidirectional neural probe engineered from polyimide. This probe is distinguished by its ability to facilitate high-resolution recordings and precise stimulation control in deep brain regions. Electrodes enhanced with a PEDOT:PSS/IrOx composite exhibit a substantial increase in charge storage capacity, escalating from 0.14 ± 0.01 mC/cm2 to an impressive 24.75 ± 0.18 mC/cm2. This augmentation significantly bolsters the electrodes’ charge transfer efficacy. In tandem, we observed a notable reduction in electrode impedance, from 3.47 ± 1.77 MΩ to a mere 41.88 ± 4.04 kΩ, while the phase angle exhibited a positive shift from −72.61 ± 1.84° to −34.17 ± 0.42°. To substantiate the electrodes’ functional prowess, we conducted in vivo experiments, where the probes were surgically implanted into the bilateral motor cortex of mice. These experiments involved the synchronous recording and meticulous analysis of neural signal fluctuations during stimulation and an assessment of the probes’ proficiency in modulating directional turning behaviors in the subjects. The empirical evidence corroborates that targeted stimulation within the bilateral motor cortex of mice can modulate the intensity of neural signals in the stimulated locale, enabling the directional control of the mice’s turning behavior to the contralateral side of the stimulation site. © 2024 by the authors.
关键词	Brain Brain computer interface Charge transfer Clinical research Conducting polymers Electrodes Electrophysiology Interface states Mammals Neurophysiology Signal analysis Behavior modulation Bilateral BCI Intracortical Modified electrodes Motor-cortex Neural probes Neural signals PEDOT/PSS PEDOT:PSS/IrOx modification Ultraflexible probe
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收录类别	EI ; SCI
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
WOS类目	Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Applied
WOS记录号	WOS:001211438600001
出版者	Multidisciplinary Digital Publishing Institute (MDPI)
EI入藏号	20241816000245
EI主题词	Probes
EI分类号	461.1 Biomedical Engineering ; 461.6 Medicine and Pharmacology ; 708.2 Conducting Materials ; 716.1 Information Theory and Signal Processing ; 722.2 Computer Peripheral Equipment ; 802.2 Chemical Reactions ; 815.1 Polymeric Materials ; 931 Classical Physics ; Quantum Theory ; Relativity ; 932 High Energy Physics ; Nuclear Physics ; Plasma Physics
原始文献类型	Journal article (JA)
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/370139
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_陶虎组
通讯作者	Wei, Xiaoling
作者单位	1.State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai; 200050, China 2.School of Graduate Study, University of Chinese Academy of Sciences, Beijing; 100049, China 3.2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai; 200050, China 4.Shanghai Laboratory Animal Research Center, Shanghai; 201203, China 5.School of Physical Science and Technology, ShanghaiTech University, Shanghai; 201210, China 6.Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing; 100049, China 7.Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai; 200031, China 8.Neuroxess Co., Ltd. (Jiangxi), Nanchang; 330029, China 9.Guangdong Institute of Intelligence Science and Technology, Zhuhai, Hengqin; 519031, China 10.Tianqiao and Chrissy Chen Institute for Translational Research, Shanghai; 200040, China
推荐引用方式 GB/T 7714	Wang, Xueying,Jiang, Wanqi,Yang, Huiran,et al. Ultraflexible PEDOT:PSS/IrOx-Modified Electrodes: Applications in Behavioral Modulation and Neural Signal Recording in Mice[J]. MICROMACHINES,2024,15(4).
APA	Wang, Xueying.,Jiang, Wanqi.,Yang, Huiran.,Ye, Yifei.,Zhou, Zhitao.,...&Wei, Xiaoling.(2024).Ultraflexible PEDOT:PSS/IrOx-Modified Electrodes: Applications in Behavioral Modulation and Neural Signal Recording in Mice.MICROMACHINES,15(4).
MLA	Wang, Xueying,et al."Ultraflexible PEDOT:PSS/IrOx-Modified Electrodes: Applications in Behavioral Modulation and Neural Signal Recording in Mice".MICROMACHINES 15.4(2024).