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ShanghaiTech University Knowledge Management System
Engineered MgO nanoparticles for cartilage-bone synergistic therapy | |
2024-03 | |
发表期刊 | SCIENCE ADVANCES (IF:11.7[JCR-2023],13.7[5-Year]) |
ISSN | 2375-2548 |
EISSN | 2375-2548 |
卷号 | 10期号:10 |
发表状态 | 已发表 |
DOI | 10.1126/sciadv.adk6084 |
摘要 | The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward comprehensive approaches that target periarticular tissues, involving both cartilage and subchondral bone. This shift drives the development of single-component therapeutics capable of acting on multiple tissues and cells. Magnesium, an element essential for maintaining skeletal health, shows promise in treating OA. However, the precise effects of magnesium on cartilage and subchondral bone are not yet clear. Here, we investigated the therapeutic effect of Mg2+ on OA, unveiling its protective effects on both cartilage and bone at the cellular and animal levels. The beneficial effect on the cartilage-bone interaction is primarily mediated by the PI3K/AKT pathway. In addition, we developed poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with nano-magnesium oxide modified with stearic acid (SA), MgO&SA@PLGA, for intra-articular injection. These microspheres demonstrated remarkable efficacy in alleviating OA in rat models, highlighting their translational potential in clinical applications. © 2024 American Association for the Advancement of Science. All rights reserved. |
关键词 | Bone Histology Magnesia Microspheres Beneficial effects Cellulars Periarticular tissues Poly lactic-co-glycolic acid Poly(lactic-co-glycolic acid) Poly(lacticco-glycolic acid) microsphere Protective effects Single components Therapeutic effects Therapeutic strategy |
URL | 查看原文 |
收录类别 | EI ; SCI |
语种 | 英语 |
资助项目 | National Key Research and Development Project[2021YFA1201404] ; National Natural Science Foundation of China[81991514] ; National Science Foundation for Youths[82202778] ; China Postdoctoral Science Foundation[2022 M722769] ; Jiangsu Provincial Key RD Program[BE2022836] ; National Key R&D Program of China["2019YFA0709200","2021YFF1200700"] ; Fundamental Research Funds for the Central Universities[202200325] ; State Key Laboratory of Analytical Chemistry for Life Science[5431ZZXM2306] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001187580500002 |
出版者 | American Association for the Advancement of Science |
EI入藏号 | 20241215762202 |
EI主题词 | Cartilage |
EI分类号 | 461.2 Biological Materials and Tissue Engineering ; 804.2 Inorganic Compounds |
原始文献类型 | Journal article (JA) |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/359915 |
专题 | 生命科学与技术学院 生命科学与技术学院_PI研究组_张翼锋组 |
通讯作者 | Zhang, Yifeng; Wei, Hui; Jiang, Qing |
作者单位 | 1.division of Sports Medicine and Adult Reconstructive Surgery, department of Orthopedic Surgery, nanjing drum tower hospital, Affiliated hospital of Medical School, nanjing University, 321 Zhongshan Road, China; 2.State Key laboratory of Pharmaceutical Biotechnology, nanjing University, China; 3.Branch of national clinical Research center for Orthopedics, Sports Medicine and Rehabilitation, China; 4.institute of Medical 3d Printing, nanjing University, China; 5.Jiangsu engineering Research center for 3d Bioprinting, Jiangsu, Nanjing; 210008, China; 6.department of Biomedical engineering, college of engineering and Applied Sciences, nanjing national laboratory of Microstructures, Jiangsu Key laboratory of Artificial Functional Materials, nanjing University, State Key laboratory of Analytical chemistry for life Science, School of chemistry and chemical engineering, chemistry and Biomedicine innovation center (chemBic), nanjing University, nanjing, Jiangsu; 210023, China; 7.department of Orthopedic Surgery, the Second Affiliated hospital, Zhejiang University School of Medicine, Orthopedics Research institute of Zhejiang University, Key laboratory of Motor System disease Research and Precision therapy of Zhejiang Province, clinical Research center of Motor System disease of Zhejiang Province, hangzhou, Zhejiang; 310000, China; 8.School of life Science and technology, Shanghaitech University, Shanghai; 201210, China; 9.Musculoskeletal Research laboratory, department of Orthopedics and traumatology, the chinese University of hong Kong, hong Kong; 999077, Hong Kong |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Zheng, Liming,Zhao, Sheng,Li, Yixuan,et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy[J]. SCIENCE ADVANCES,2024,10(10). |
APA | Zheng, Liming.,Zhao, Sheng.,Li, Yixuan.,Xu, Jiankun.,Yan, Wenjin.,...&Jiang, Qing.(2024).Engineered MgO nanoparticles for cartilage-bone synergistic therapy.SCIENCE ADVANCES,10(10). |
MLA | Zheng, Liming,et al."Engineered MgO nanoparticles for cartilage-bone synergistic therapy".SCIENCE ADVANCES 10.10(2024). |
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