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Engineered MgO nanoparticles for cartilage-bone synergistic therapy
2024-03
发表期刊SCIENCE ADVANCES (IF:11.7[JCR-2023],13.7[5-Year])
ISSN2375-2548
EISSN2375-2548
卷号10期号:10
发表状态已发表
DOI10.1126/sciadv.adk6084
摘要

The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward comprehensive approaches that target periarticular tissues, involving both cartilage and subchondral bone. This shift drives the development of single-component therapeutics capable of acting on multiple tissues and cells. Magnesium, an element essential for maintaining skeletal health, shows promise in treating OA. However, the precise effects of magnesium on cartilage and subchondral bone are not yet clear. Here, we investigated the therapeutic effect of Mg2+ on OA, unveiling its protective effects on both cartilage and bone at the cellular and animal levels. The beneficial effect on the cartilage-bone interaction is primarily mediated by the PI3K/AKT pathway. In addition, we developed poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with nano-magnesium oxide modified with stearic acid (SA), MgO&SA@PLGA, for intra-articular injection. These microspheres demonstrated remarkable efficacy in alleviating OA in rat models, highlighting their translational potential in clinical applications. © 2024 American Association for the Advancement of Science. All rights reserved.

关键词Bone Histology Magnesia Microspheres Beneficial effects Cellulars Periarticular tissues Poly lactic-co-glycolic acid Poly(lactic-co-glycolic acid) Poly(lacticco-glycolic acid) microsphere Protective effects Single components Therapeutic effects Therapeutic strategy
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收录类别EI ; SCI
语种英语
资助项目National Key Research and Development Project[2021YFA1201404] ; National Natural Science Foundation of China[81991514] ; National Science Foundation for Youths[82202778] ; China Postdoctoral Science Foundation[2022 M722769] ; Jiangsu Provincial Key RD Program[BE2022836] ; National Key R&D Program of China["2019YFA0709200","2021YFF1200700"] ; Fundamental Research Funds for the Central Universities[202200325] ; State Key Laboratory of Analytical Chemistry for Life Science[5431ZZXM2306]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:001187580500002
出版者American Association for the Advancement of Science
EI入藏号20241215762202
EI主题词Cartilage
EI分类号461.2 Biological Materials and Tissue Engineering ; 804.2 Inorganic Compounds
原始文献类型Journal article (JA)
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/359915
专题生命科学与技术学院
生命科学与技术学院_PI研究组_张翼锋组
通讯作者Zhang, Yifeng; Wei, Hui; Jiang, Qing
作者单位
1.division of Sports Medicine and Adult Reconstructive Surgery, department of Orthopedic Surgery, nanjing drum tower hospital, Affiliated hospital of Medical School, nanjing University, 321 Zhongshan Road, China;
2.State Key laboratory of Pharmaceutical Biotechnology, nanjing University, China;
3.Branch of national clinical Research center for Orthopedics, Sports Medicine and Rehabilitation, China;
4.institute of Medical 3d Printing, nanjing University, China;
5.Jiangsu engineering Research center for 3d Bioprinting, Jiangsu, Nanjing; 210008, China;
6.department of Biomedical engineering, college of engineering and Applied Sciences, nanjing national laboratory of Microstructures, Jiangsu Key laboratory of Artificial Functional Materials, nanjing University, State Key laboratory of Analytical chemistry for life Science, School of chemistry and chemical engineering, chemistry and Biomedicine innovation center (chemBic), nanjing University, nanjing, Jiangsu; 210023, China;
7.department of Orthopedic Surgery, the Second Affiliated hospital, Zhejiang University School of Medicine, Orthopedics Research institute of Zhejiang University, Key laboratory of Motor System disease Research and Precision therapy of Zhejiang Province, clinical Research center of Motor System disease of Zhejiang Province, hangzhou, Zhejiang; 310000, China;
8.School of life Science and technology, Shanghaitech University, Shanghai; 201210, China;
9.Musculoskeletal Research laboratory, department of Orthopedics and traumatology, the chinese University of hong Kong, hong Kong; 999077, Hong Kong
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Zheng, Liming,Zhao, Sheng,Li, Yixuan,et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy[J]. SCIENCE ADVANCES,2024,10(10).
APA Zheng, Liming.,Zhao, Sheng.,Li, Yixuan.,Xu, Jiankun.,Yan, Wenjin.,...&Jiang, Qing.(2024).Engineered MgO nanoparticles for cartilage-bone synergistic therapy.SCIENCE ADVANCES,10(10).
MLA Zheng, Liming,et al."Engineered MgO nanoparticles for cartilage-bone synergistic therapy".SCIENCE ADVANCES 10.10(2024).
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