Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites

doi:10.1002/adma.202402981

	Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites
	Liu, Yuxin 1,2,3; Wei, Zheng 2; Zhang, Jieying4 ; Xu, Yang 5; Zhou, Jing 5; Ma, Zhanfang 5; Mutti, Francesco G.2; Zhang, Hong 2; Zhu, Xingjun4 ; Loeffler, Felix F.1
	2024
发表期刊	ADVANCED MATERIALS (IF:27.4[JCR-2023],30.2[5-Year])
ISSN	0935-9648
EISSN	1521-4095
卷号	36 期号:23
发表状态	已发表
DOI	10.1002/adma.202402981
摘要	The photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength-dependent optical attenuation properties of tissues, the tumor depth is assessed using a multichannel lanthanide nanocomposite. A zeolitic imidazolate framework (ZIF-8)-coated nanocomposite is able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen-bonding network formed by the encapsulated highly polarized polyoxometalate guest. It is superior to both bare and PEGylated ZIF-8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues. © 2024 The Authors. Advanced Materials published by Wiley-VCH GmbH.
关键词	Controlled drug delivery Damage detection Fluorescence Histology Hydrogen bonds Nanocomposites Optical properties Proteins Rare earth elements Targeted drug delivery Doped nanoparticles Fluorescent probes Heat shock protein Lanthanide-doped nanoparticle Multi channel Optical attenuation Photothermal therapeutics Photothermal therapy Therapeutic effects Thermal sensitivity
收录类别	EI
语种	英语
出版者	John Wiley and Sons Inc
EI入藏号	20241315829622
EI主题词	Tumors
EI分类号	461.2 Biological Materials and Tissue Engineering ; 547.2 Rare Earth Metals ; 741.1 Light/Optics ; 761 Nanotechnology ; 801.4 Physical Chemistry ; 804.1 Organic Compounds ; 933 Solid State Physics
原始文献类型	Article in Press
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/359900
专题	物质科学与技术学院物质科学与技术学院_本科生物质科学与技术学院_博士生物质科学与技术学院_PI研究组_朱幸俊组
通讯作者	Zhang, Hong; Zhu, Xingjun; Loeffler, Felix F.
作者单位	1.Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam; 14476, Germany; 2.Van’ t Hoff Institute for Molecular Sciences, Molecular Photonics & HIMS-Biocat, University of Amsterdam, Amsterdam; 1098 XH, Netherlands; 3.Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin; 14195, Germany; 4.School of Physical Science and Technology & State Key Laboratory of Advanced Medical Materials and Devices, Shanghai Tech University, Shanghai; 201210, China; 5.Beijing Key Laboratory for Optical Materials and Photonic Devices, Capital Normal University, Beijing; 100048, China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Liu, Yuxin,Wei, Zheng,Zhang, Jieying,et al. Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites[J]. ADVANCED MATERIALS,2024,36(23).
APA	Liu, Yuxin.,Wei, Zheng.,Zhang, Jieying.,Xu, Yang.,Zhou, Jing.,...&Loeffler, Felix F..(2024).Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites.ADVANCED MATERIALS,36(23).
MLA	Liu, Yuxin,et al."Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites".ADVANCED MATERIALS 36.23(2024).