上海科技大学知识管理系统

CTP synthase (CTPS), the rate-limiting enzyme in the de novo synthesis of CTP, assembles
into a filamentous structure termed the cytoophidium. The Hippo pathway regulates cell proliferation
and apoptosis. The relationship of the nucleotide metabolism with the Hippo pathway is little known.
Here, we study the impact of the Hippo pathway on the cytoophidium in Drosophila melanogaster
posterior follicle cells (PFCs). We find that the inactivation of the Hippo pathway correlates with
reduced cytoophidium length and number within PFCs. During the overexpression of CTPS, the
presence of Hippo mutations also reduces the length of cytoophidia in PFCs. In addition, we observe
that knocking down CTPS mitigates hpo (Hippo)-associated over-proliferation. In summary, our
results suggest that there is a connection between the Hippo pathway and the nucleotide biosynthesis
enzyme CTPS in PFCs.