ShanghaiTech University Knowledge Management System
| Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against emerged mutational variants | |
Tingting Li1; Xiaojian Han1; Chenjian Gu2; Hangtian Guo3; Huajun Zhang4; Yingming Wang1; Chao Hu1; Kai Wang1; Fengjia Liu3; Feiyang Luo1; Jie Hu1; Wang Wang1; Shenglong Li1; Yanan Hao1; Meiying Shen5; Jingjing Huang1; Yingyi Long1; Shuyi Song1; Ruixin Wu1; Song Mu1; Qian Chen1; Fengxia Gao1; Jianwei Wang1; Shunhua Long1; Luo Li1; Youhua Xie2; Haitao Yang3  ; Bo Zhang4; Ailong Huang1; Aishun Jin1
| |
| 2021-10-21 | |
| 会议录名称 | 第十四届全国免疫学学术大会论文摘要汇编 |
| 页码 | 1 |
| 摘要 | Accumulating mutations in the SARS-CoV-2 Spike(S) protein can increase the possibility of immune escape,challenging the present COVID-19 prophylaxis and clinical interventions.Here,3 receptor binding domain(RBD) specific monoclonal antibodies(mAbs),58 G6,510 A5 and 13 G9,with high neutralizing potency blocking authentic SARS-CoV-2 virus displayed remarkable efficacy against authentic B.1.351 virus.Surprisingly,structural analysis revealed that 58 G6 and 13 G9 both recognized the steric region S470-495 on the RBD,overlapping the E484 K mutation presented in B.1.351.Also,58 G6 directly bound to another region S450-458 in the RBD.Significantly,58 G6 and 510 A5 both demonstrated prophylactic efficacy against authentic SARS-CoV-2 and B.1.351 viruses in the transgenic mice expressing human ACE2(hACE2),protecting weight loss and reducing virus loads.Together,we have evidenced 2 ultrapotent neutralizing Abs with unique mechanism targeting authentic SARS-CoV-2 mutants,which can be promising candidates to fulfill the urgent needs for the prolonged COVID-19 pandemic. |
| 会议名称 | 第十四届全国免疫学学术大会 |
| 会议地点 | 中国 四川成都 |
| URL | 查看原文 |
| 语种 | 中文 |
| 原始文献类型 | 中国会议 |
| 来源库 | CNKI |
| 文献类型 | 会议论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/350109 |
| 专题 | 免疫化学研究所_PI研究组_杨海涛组 |
| 作者单位 | 1.ChongqingMedicalUniversity; 2.复旦大学; 3.上海科技大学; 4.武汉病毒研究所; 5.哈尔滨医科大学 |
| 推荐引用方式 GB/T 7714 | Tingting Li,Xiaojian Han,Chenjian Gu,et al. Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against emerged mutational variants[C],2021:1. |
| 条目包含的文件 | ||||||
| 条目无相关文件。 | ||||||
修改评论
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。