Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke

doi:10.1021/acsnano.3c10982

	Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke
	Liao, Jun 1,2; Li, Yi 1; Fan, Li 2; Sun, Yuhan 2; Gu, Zhengyan 2; Xu, Qing-Qiang 3; Wang, Yun 1; Xiong, Liyan 1; Xiao, Kai 3; Chen, Zhe-Sheng 5; Ma, Zhiwei4 ; Zhang, Chuan 1; Wang, Tingfang 1; Lu, Ying 2
	2024
发表期刊	ACS NANO (IF:15.8[JCR-2023],16.2[5-Year])
ISSN	1936-0851
EISSN	1936-086X
发表状态	已发表
DOI	10.1021/acsnano.3c10982
摘要	Overproduction of reactive oxygen species by damaged mitochondria after ischemia is a key factor in the subsequent cascade of damage. Delivery of therapeutic agents to the mitochondria of damaged neurons in the brain is a potentially promising targeted therapeutic strategy for the treatment of ischemic stroke. In this study, we developed a ceria nanoenzymes synergistic drug-carrying nanosystem targeting mitochondria to address multiple factors of ischemic stroke. Each component of this nanosystem works individually as well as synergistically, resulting in a comprehensive therapy. Alleviation of oxidative stress and modulation of the mitochondrial microenvironment into a favorable state for ischemic tolerance are combined to restore the ischemic microenvironment by bridging mitochondrial and multiple injuries. This work also revealed the detailed mechanisms by which the proposed nanodelivery system protects the brain, which represents a paradigm shift in ischemic stroke treatment. © 2024 American Chemical Society
关键词	Mitochondria Nanosystems Oxygen Bioactives Ceria nanozyme Ischemic strokes Microenvironments Mitochondrial Mitochondrias Nanocarriers Nanoenzyme Reactive oxygen species Reperfusion injury
收录类别	SCI ; SCIE ; EI
语种	英语
出版者	American Chemical Society
EI入藏号	20240715549520
EI主题词	Cerium oxide
EI分类号	461.2 Biological Materials and Tissue Engineering ; 761 Nanotechnology ; 804 Chemical Products Generally ; 804.2 Inorganic Compounds ; 933 Solid State Physics
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/349701
专题	生物医学工程学院生物医学工程学院_PI研究组_马智炜组
通讯作者	Ma, Zhiwei; Zhang, Chuan; Wang, Tingfang; Lu, Ying
作者单位	1.Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai; 200444, China 2.Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai; 200433, China 3.Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Naval Medical University, Shanghai; 200433, China 4.School of Biomedical Engineering, ShanghaiTech University, Shanghai; 201210, China 5.Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens; NY; 11439, United States
通讯作者单位	生物医学工程学院
推荐引用方式 GB/T 7714	Liao, Jun,Li, Yi,Fan, Li,et al. Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke[J]. ACS NANO,2024.
APA	Liao, Jun.,Li, Yi.,Fan, Li.,Sun, Yuhan.,Gu, Zhengyan.,...&Lu, Ying.(2024).Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke.ACS NANO.
MLA	Liao, Jun,et al."Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke".ACS NANO (2024).