上海科技大学知识管理系统

本发明提供了以下化合物(I)或者其药学上可接受的盐、酯、光学异构体、互变异构体、立体异构体、多晶型物、溶剂合物、N-氧化物、同位素标记的化合物、代谢物、螯合物、络合物、包合物或前药，以及含有本发明的化合物的药物组合物，还提供本发明化合物作为一型细胞凋亡信号调节激酶ASK1抑制剂的用途，以及在与一型细胞凋亡信号调节激酶ASK1相关疾病药物制备中的应用，及相应的药物组合物。

The present invention provides the following compound (I) or a pharmaceutically acceptable salt, an ester, an optical isomer, a tautomer, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotope-labeled compound, a metabolite, a chelate, a complex, a clathrate, or a prodrug thereof, and a pharmaceutical composition comprising the compound of the present invention. Also provided are use of the compound of the present invention as an apoptosis signal-regulating kinase 1 (ASK1) inhibitor, use of the compound in the preparation of a drug for related apoptosis signal-regulating kinase 1 (ASK1) diseases, and a corresponding pharmaceutical composition.