上海科技大学知识管理系统

Background T1, T2 and T1 rho are well-recognized parameters for quantitative cardiac MRI. Simultaneous estimation of these parameters allows for comprehensive myocardial tissue characterization, such as myocardial fibrosis and edema. However, conventional techniques either quantify the parameters individually with separate breath-hold acquisitions, which may result in unregistered parameter maps, or estimate multiple parameters in a prolonged breath-hold acquisition, which may be intolerable to patients. We propose a free-breathing multi-parametric mapping (FB-MultiMap) technique that provides co-registered myocardial T1, T2 and T1 rho maps in a single efficient acquisition.Methods The proposed FB-MultiMap performs electrocardiogram-triggered single-shot Cartesian acquisition over 16 consecutive cardiac cycles, where inversion, T2 and T1 rho preparations are introduced for varying contrasts. A diaphragmatic navigator was used for prospective through-plane motion correction and the in-plane motion was corrected retrospectively with a group-wise image registration method. Quantitative mapping was conducted through dictionary matching of the motion corrected images, where the subject-specific dictionary was created using Bloch simulations for a range of T1, T2 and T1 rho values, as well as B1 factors to account for B1 inhomogeneities. The FB-MultiMap was optimized and validated in numerical simulations, phantom experiments, and in vivo imaging of 15 healthy subjects and six patients with suspected cardiac diseases.Results The phantom T1, T2 and T1 rho values estimated with FB-MultiMap agreed well with reference measurements with no dependency on heart rate. In healthy subjects, FB-MultiMap T1 was higher than MOLLI T1 mapping (1218 +/- 50 ms vs. 1166 +/- 38 ms, p < 0.001). The myocardial T2 and T1 rho estimated with FB-MultiMap were lower compared to the mapping with T2-or T1 rho-prepared 2D balanced steady-state free precession (T2: 41.2 +/- 2.8 ms vs. 42.5 +/- 3.1 ms, p = 0.06; T1 rho: 45.3 +/- 4.4 ms vs. 50.2 +/- 4.0, p < 0.001). The pathological changes in myocardial parameters measured with FB-MultiMap were consistent with conventional techniques in all patients.Conclusion The proposed free-breathing multi-parametric mapping technique provides co-registered myocardial T1, T2 and T1 rho maps in 16 heartbeats, achieving similar mapping quality to conventional breath-hold mapping methods.