Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis

doi:10.1016/j.celrep.2023.113288

	Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis
	Lv, Zhenyu 1,4; Meng, Jiao 1; Yao, Sheng 2,3,4,5; Xiao, Fu 6,7; Li, Shilong 1,4; Shi, Haoyang 1,4; Cui, Chen 4,7; Chen, Kaixian 4,6,7; Luo, Xiaomin 4,6,7; Ye, Yang2,3,4,6,8 ; Chen, Chang 1,4,9
	2023-11-28
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	42 期号:11
发表状态	已发表
DOI	10.1016/j.celrep.2023.113288
摘要	Skeletal muscle function declines in the aging process or disease; however, until now, skeletal muscle has remained one of the organs most undertreated with medication. In this study, naringenin (NAR) was found to build muscle endurance in wild-type mice of different ages by increasing oxidative myofiber numbers and aerobic metabolism, and it ameliorates muscle dysfunction in mdx mice. The transcription factor Sp1 was identified as a direct target of NAR and was shown to mediate the function of NAR on muscle. Moreover, the binding site of NAR on Sp1 was further validated as GLN-110. NAR enhances the binding of Sp1 to the CCCTGCCCTC sequence of the Esrrg promoter by promoting Sp1 phosphorylation, thus upregulating Esrrg expression. The identification of the Sp1-ERRg transcriptional axis is of great significance in basic muscle research, and this function of NAR has potential implications for the improvement of muscle function and the prevention of muscle atrophy.
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收录类别	SCI
语种	英语
资助项目	Ningxia Key Research and Development Program Grant[XDB39000000] ; Regional key projects of science and technology service network plan (STS plan) of Chinese Academy of Sciences[2016BZ05] ; National Natural Science Foundation of China[KFJ-STS-QYZD-181] ; Key Area Research and Development Program of Guangdong Province[82173696] ; null[2020B030370002]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:001096843100001
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/346500
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Luo, Xiaomin; Ye, Yang; Chen, Chang
作者单位	1.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Drug & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 9.Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Lv, Zhenyu,Meng, Jiao,Yao, Sheng,et al. Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis[J]. CELL REPORTS,2023,42(11).
APA	Lv, Zhenyu.,Meng, Jiao.,Yao, Sheng.,Xiao, Fu.,Li, Shilong.,...&Chen, Chang.(2023).Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis.CELL REPORTS,42(11).
MLA	Lv, Zhenyu,et al."Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis".CELL REPORTS 42.11(2023).