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Cellulose nanofibril matrix drives the dynamic formation of spheroids | |
2023-10-01 | |
发表期刊 | JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (IF:4.7[JCR-2023],4.1[5-Year]) |
ISSN | 1673-1581 |
EISSN | 1862-1783 |
卷号 | 24期号:10 |
发表状态 | 已发表 |
DOI | 10.1631/jzus.B23d0003 |
摘要 | Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 h) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids. |
关键词 | Cellulose Nanofibril Matrix Self-assembly Spheroid |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | This work was supported by the National Natural Science Foundation of China (No. 32071347), the ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University (No. 02020200-K02013008), the Joint Laboratory Grant from Jiangsu Wuzhon[32071347] ; National Natural Science Foundation of China[02020200-K02013008] |
WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
WOS类目 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
WOS记录号 | WOS:001087608300006 |
出版者 | ZHEJIANG UNIV PRESS |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/345897 |
专题 | 物质科学与技术学院 物质科学与技术学院_PI研究组_龚晋慷组 |
通讯作者 | Yao, Yuan |
作者单位 | 1.Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China 2.Zhejiang Univ, ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Lu, Yi,Li, Guo,Li, Yeqiu,et al. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2023,24(10). |
APA | Lu, Yi,Li, Guo,Li, Yeqiu,&Yao, Yuan.(2023).Cellulose nanofibril matrix drives the dynamic formation of spheroids.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,24(10). |
MLA | Lu, Yi,et al."Cellulose nanofibril matrix drives the dynamic formation of spheroids".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 24.10(2023). |
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