Cellulose nanofibril matrix drives the dynamic formation of spheroids
2023-10-01
发表期刊JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (IF:4.7[JCR-2023],4.1[5-Year])
ISSN1673-1581
EISSN1862-1783
卷号24期号:10
发表状态已发表
DOI10.1631/jzus.B23d0003
摘要

Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 h) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids.

关键词Cellulose Nanofibril Matrix Self-assembly Spheroid
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收录类别SCI
语种英语
资助项目This work was supported by the National Natural Science Foundation of China (No. 32071347), the ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University (No. 02020200-K02013008), the Joint Laboratory Grant from Jiangsu Wuzhon[32071347] ; National Natural Science Foundation of China[02020200-K02013008]
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号WOS:001087608300006
出版者ZHEJIANG UNIV PRESS
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/345897
专题物质科学与技术学院
物质科学与技术学院_PI研究组_龚晋慷组
通讯作者Yao, Yuan
作者单位
1.Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China
2.Zhejiang Univ, ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Peoples R China
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
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GB/T 7714
Lu, Yi,Li, Guo,Li, Yeqiu,et al. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2023,24(10).
APA Lu, Yi,Li, Guo,Li, Yeqiu,&Yao, Yuan.(2023).Cellulose nanofibril matrix drives the dynamic formation of spheroids.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,24(10).
MLA Lu, Yi,et al."Cellulose nanofibril matrix drives the dynamic formation of spheroids".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 24.10(2023).
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