Post-translational modifications in stress granule and their implications in neurodegenerative diseases

doi:10.1016/j.bbagrm.2023.194989

	Post-translational modifications in stress granule and their implications in neurodegenerative diseases
	Wang, Zhangshun; Zhang, Chen'ang; Fan, Chengyu; Liu, Yanfen
	2023-12-01
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (IF:2.6[JCR-2023],3.6[5-Year])
ISSN	1874-9399
EISSN	1876-4320
卷号	1866 期号:4
发表状态	已发表
DOI	10.1016/j.bbagrm.2023.194989
摘要	Stress granules (SGs) arise as formations of mRNAs and proteins in response to translation initiation inhibition during stress. These dynamic compartments adopt a fluidic nature through liquid-liquid phase separation (LLPS), exhibiting a composition subject to constant change within cellular contexts. Research has unveiled an array of post-translational modifications (PTMs) occurring on SG proteins, intricately orchestrating SG dynamics. In the realm of neurodegenerative diseases, pathological mutant proteins congregate into insoluble aggregates alongside numerous SG proteins, manifesting resilience against disassembly. Specific PTMs conspicuously label these aggregates, designating them for subsequent degradation. The strategic manipulation of aberrant SGs via PTMs emerges as a promising avenue for therapeutic intervention. This review discerns recent strides in comprehending the impact of PTMs on LLPS behavior and the assembly/disassembly kinetics of SGs. By delving into the roles of PTMs in governing SG dynamics, we augment our cognizance of the molecular underpinnings of neurodegeneration. Furthermore, we offer invaluable insights into potential targets for therapeutic intervention in neurodegenerative afflictions, encompassing conditions like amyotrophic lateral sclerosis and frontotemporal dementia.
关键词	Liquid-liquid phase separation Neurodegenerative disease Post-translational modification RNA-binding protein Stress granule Ubiquitination
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[32070697] ; ShanghaiTech University start-up fund[2015F0202-000]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:001086091700001
出版者	ELSEVIER
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/345772
专题	生命科学与技术学院生命科学与技术学院_PI研究组_刘艳芬组生命科学与技术学院_公共科研平台_分子影像平台生命科学与技术学院_硕士生生命科学与技术学院_博士生
共同第一作者	Zhang, Chen'ang
通讯作者	Liu, Yanfen
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Zhangshun,Zhang, Chen'ang,Fan, Chengyu,et al. Post-translational modifications in stress granule and their implications in neurodegenerative diseases[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2023,1866(4).
APA	Wang, Zhangshun,Zhang, Chen'ang,Fan, Chengyu,&Liu, Yanfen.(2023).Post-translational modifications in stress granule and their implications in neurodegenerative diseases.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1866(4).
MLA	Wang, Zhangshun,et al."Post-translational modifications in stress granule and their implications in neurodegenerative diseases".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1866.4(2023).