The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma

doi:10.2147/JHC.S433948

	The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma
	Zhang, Yunfei 1,2; Sheng, Ruofan 1,2; Yang, Chun 2; Dai, Yongming3 ; Zeng, Mengsu 1,2,4
	2023
发表期刊	JOURNAL OF HEPATOCELLULAR CARCINOMA (IF:4.2[JCR-2023],4.1[5-Year])
EISSN	2253-5969
卷号	10
发表状态	已发表
DOI	10.2147/JHC.S433948
摘要	Purpose: To assess the effectiveness of tri-exponential Intra-Voxel Incoherent Motion (tri-IVIM) MRI in preoperatively identifying microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Patients and Methods: In this prospective study, 67 patients with HCC were included. Metrics from bi-exponential IVIM (bi-IVIM) and tri-IVIM were calculated. Subgroup comparisons were analyzed using the independent Student's t-test or Mann-Whitney U-test. Logistic regression was performed to explore clinical risk factors. Diagnostic performance was assessed using receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis.Results: MVI-positive HCCs exhibited significantly lower true diffusion coefficient (Dt) from bi-IVIM, as well as fast-diffusion coefficients (Df) and slow-diffusion coefficients (Ds) from tri-IVIM, compared to MVI-negative HCCs (p < 0.05). Tumor size and alpha-fetoprotein (AFP) were identified as risk factors. The combination of tri-IVIM-derived metrics (Ds and Df) yielded higher diagnostic accuracy (AUC = 0.808) compared to bi-IVIM (AUC = 0.741). A predictive model based on a nomogram was constructed using Ds, Df, tumor size, and AFP, resulting in the highest diagnostic accuracy (AUC = 0.859). Decision curve analysis indicated that the constructed model, provided the highest net benefit by accurately stratifying the risk of MVI, followed by tri-IVIM and bi-IVIM.Conclusion: Tri-IVIM can provide information on perfusion and diffusion for evaluating MVI in HCC. Additionally, tri-IVIM outperformed bi-IVIM in identifying MVI-positive HCC. By integrating clinical risk factors and metrics from tri-IVIM, a predictive nomogram exhibited the highest diagnostic accuracy, potentially aiding in the noninvasive and preoperative assessment of MVI.
关键词	tri-exponential intra-voxel incoherent motion diffusion weighted imaging hepatocellular carcinoma microvascular invasion
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:001081163200001
出版者	DOVE MEDICAL PRESS LTD
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/343598
专题	生物医学工程学院生物医学工程学院_PI研究组_胡鹏组
通讯作者	Dai, Yongming; Zeng, Mengsu
作者单位	1.Fudan Univ, Shanghai Inst Med Imaging, Shanghai 200032, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Dept Radiol, Shanghai 200032, Peoples R China 3.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 200032, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Radiol, 180 Fenglin Rd, Shanghai 200032, Peoples R China
通讯作者单位	生物医学工程学院
推荐引用方式 GB/T 7714	Zhang, Yunfei,Sheng, Ruofan,Yang, Chun,et al. The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma[J]. JOURNAL OF HEPATOCELLULAR CARCINOMA,2023,10.
APA	Zhang, Yunfei,Sheng, Ruofan,Yang, Chun,Dai, Yongming,&Zeng, Mengsu.(2023).The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma.JOURNAL OF HEPATOCELLULAR CARCINOMA,10.
MLA	Zhang, Yunfei,et al."The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma".JOURNAL OF HEPATOCELLULAR CARCINOMA 10(2023).