上海科技大学知识管理系统

["Rationale and Objectives: To noninvasively and preoperatively identify the microvascular invasion (MVI) of hepatocellular carcinoma (HCC) with the restricted spectrum imaging (RSI).","Materials and Methods: 62 patients were included into this prospective study and underwent the RSI examination with a 3.0-T scanner. Mono-exponential diffusion-weighted imaging-derived apparent diffusion coefficient (ADC) and RSI-derived metrics including f(1) (fraction of restricted diffusion), f(2) (fraction of hindered diffusion), f(3) (fraction of free diffusion), and f(1)f(2) (the multiply of f(1) and f(2)) were calculated. Univariate and multivariate logistic regression were used to select the independent risk factors. Nomogram-based model was constructed with the selected indexes. Receiver operative characteristics analysis and calibration curve were used to evaluate the diagnostic accuracy.","Results: MVI-positive HCC showed significantly higher f(1) and lower ADC values (ADC: 1.549 +/- 0.228 x 10(-3) vs 1.365 +/- 0.239 x10(-3) mm(2)/s, P=.003; f(1): 0.1633 +/- 0.0341 vs 0.2221 +/- 0.0491, P <.001). Tumor size and f(1) were selected as independent risk factors for MVI. The nomogram-based model was then constructed with tumor size and f(1). Nomogram-based model (area under ROC curve [AUC]=0.856) yielded the best diagnostic accuracy followed by f(1) (AUC=0.842) and ADC (AUC=0.708). The AUC of both the f(1) and nomogram model were significantly higher than that of ADC.","Conclusion: RSI-derived metrics can be utilized to noninvasively and efficiently identify the MVI of HCC. Considering the importance of MVI as a significant prognostic factor for HCC, the utilization of RSI has the potential to assist in prognostic prediction and clinical management."]