Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer

doi:10.1093/bfgp/ely018

	Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer
	Yin, Qinan 2; Tang, Jiaxing1 ; Zhu, Xuekai3
	2019-03
发表期刊	BRIEFINGS IN FUNCTIONAL GENOMICS (IF:2.5[JCR-2023],3.4[5-Year])
ISSN	2041-2649
卷号	18 期号:2 页码:119-128
发表状态	已发表
DOI	10.1093/bfgp/ely018
摘要	Next-generation sequencing has produced a large quantity of DNA or RNA sequences related to the processes occurring within tumors and their microenvironment in a reasonable time and cost. These data have been used to guide the identification of neoantigens and to determine their specific T-cell receptors. Furthermore, adoptive T-cell therapy targeting neoantigens is under development for cancer treatment. In this review, we first provide an overview of sequencing technologies and the updated findings concerning neoantigens related to adoptive T-cell therapy and then summarize the methods and principles underlying the development of next-generation sequencing-based neoantigen-reactive T-cell therapy for cancer.
关键词	next-generation sequencing neoantigen T-cell therapy TILs TCR-engineered T cells
收录类别	SCI ; SCIE
语种	英语
资助项目	Yunnan Provincial Science and Technology Department Projects[2016FC007] ; Yunnan Provincial Science and Technology Department Projects[2017IB020]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000462706800006
出版者	OXFORD UNIV PRESS
WOS关键词	TUMOR-INFILTRATING LYMPHOCYTES ; METASTATIC MELANOMA ; NEOANTIGEN LANDSCAPE ; CHECKPOINT BLOCKADE ; ANALYSIS REVEALS ; POINT MUTATION ; RNA-SEQ ; ANTIGENS ; IDENTIFICATION ; PEPTIDE
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34251
专题	生命科学与技术学院_博士生免疫化学研究所_PI研究组_朱学锴组 T细胞工程实验室
通讯作者	Zhu, Xuekai
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 2.NIH, Ctr Clin, Bethesda, MD 20892 USA 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Biol, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Yin, Qinan,Tang, Jiaxing,Zhu, Xuekai. Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer[J]. BRIEFINGS IN FUNCTIONAL GENOMICS,2019,18(2):119-128.
APA	Yin, Qinan,Tang, Jiaxing,&Zhu, Xuekai.(2019).Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer.BRIEFINGS IN FUNCTIONAL GENOMICS,18(2),119-128.
MLA	Yin, Qinan,et al."Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer".BRIEFINGS IN FUNCTIONAL GENOMICS 18.2(2019):119-128.