Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain

doi:10.1186/s10020-019-0076-3

	Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain
	Li, Sha 1; Zhang, Han2,3,4 ; Wang, Aifang 2,3; Liu, Yan3,4,5 ; Liu, Houqi 6; Yue, Feng 7; Abulaiti, Xianmixinuer 2,8,9; Zhang, Caiqiao 1; Li, Lingsong2,3,4,5,8,9
	2019-03-29
发表期刊	MOLECULAR MEDICINE
ISSN	1076-1551
卷号	25
发表状态	已发表
DOI	10.1186/s10020-019-0076-3
摘要	Background: Cell therapy is proposed to be a potential treatment for Parkinson's disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has been raised over the issue of whether such cells can be reprogrammed into dopamine-producing cells for therapeutic efficacy. Here, we aim to investigate whether adult human RPE cells can be reprogrammed into dopamine-producing cells both in vitro and in the recipient monkey brain.
关键词	Cell-replacement therapy Parkinson's disease Retinal pigment epithelium Chemically induced reprogramming
收录类别	SCI ; SCIE
语种	英语
资助项目	Foundation of Henan Provincial People's Hospital[Y765001H21]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine
WOS类目	Biochemistry & Molecular Biology ; Cell Biology ; Medicine, Research & Experimental
WOS记录号	WOS:000463388700001
出版者	SPRINGER
WOS关键词	EMBRYONIC STEM-CELLS ; PARKINSONS-DISEASE ; HUMAN ES ; NEURAL PROGENITORS ; NEURONS ; TRANSPLANTATION ; DEFICIT ; MODEL
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34184
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_李凌松组生命科学与技术学院_博士生
通讯作者	Abulaiti, Xianmixinuer; Li, Lingsong
作者单位	1.Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai 201210, Peoples R China 6.Second Mil Med Univ, Res Ctr Dev Biol, Shanghai 200433, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Dept Neurobiol, Beijing 100053, Peoples R China 8.Henan Univ, Henan Prov Peoples Hosp, Henan Key Lab Stem Cell Differentiat & Modificat, Zhengzhou, Henan, Peoples R China 9.Zhengzhou Univ, Zhengzhou, Henan, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Sha,Zhang, Han,Wang, Aifang,et al. Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain[J]. MOLECULAR MEDICINE,2019,25.
APA	Li, Sha.,Zhang, Han.,Wang, Aifang.,Liu, Yan.,Liu, Houqi.,...&Li, Lingsong.(2019).Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain.MOLECULAR MEDICINE,25.
MLA	Li, Sha,et al."Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain".MOLECULAR MEDICINE 25(2019).