Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones

doi:10.1002/anie.201814751

	Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones
	Zhang, Linli 1,2; Tang, Yitian1,3 ; Han, Zhaobin 1; Ding, Kuiling1,2,3,4
	2019-04
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN	1433-7851
卷号	58 期号:15 页码:4973-4977
发表状态	已发表
DOI	10.1002/anie.201814751
摘要	A series of Mn-I complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, and excellent enantioselectivities (85-98% ee) in the hydrogenation of various ketones. These aspects are rare in earth-abundant metal catalyzed hydrogenations. The utility of the protocol have been demonstrated in the asymmetric synthesis of a variety of key intermediates for chiral drugs. Preliminary mechanistic investigations indicate that an outer-sphere mode of substrate-catalyst interactions probably dominates the catalysis.
关键词	asymmetric catalysis hydrogenation ketones manganese PNN ligands
收录类别	SCI ; SCIE ; EI ; IC ; CCR
语种	英语
资助项目	Youth Innovation promotion Association CAS[2015205]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000463739900030
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20191106627444
EI主题词	Catalysis ; Catalysts ; Enantioselectivity ; Ketones ; Ligands ; Manganese ; Manganese compounds ; Polyols
WOS关键词	ASYMMETRIC HYDROGENATION ; PRESSURE HYDROGENATION ; PHOSPHORUS LIGANDS ; IRON(II) COMPLEXES ; COBALT COMPLEXES ; ARYL ; HYDROCHLORIDES
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34180
专题	物质科学与技术学院_博士生物质科学与技术学院_特聘教授组_丁奎岭组
通讯作者	Han, Zhaobin; Ding, Kuiling
作者单位	1.Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 4.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Linli,Tang, Yitian,Han, Zhaobin,et al. Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(15):4973-4977.
APA	Zhang, Linli,Tang, Yitian,Han, Zhaobin,&Ding, Kuiling.(2019).Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(15),4973-4977.
MLA	Zhang, Linli,et al."Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.15(2019):4973-4977.