Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

doi:10.1038/s41565-019-0373-6

	Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment
	Gong, Ningqiang 1,2,3,4; Ma, Xiaowei 1,2; Ye, Xiaoxia 1,2; Zhou, Qunfang 5; Chen, Xiaoai 1,2; Tan, Xiaoli 6; Yao, Shengkun7 ; Huo, Shuaidong 1,2; Zhang, Tingbin 1,2; Chen, Shizhu 1,2,8; Teng, Xucong 3; Hu, Xixue 1,2; Yu, Jie 5; Gan, Yaling 1,2; Jiang, Huaidong7 ; Li, Jinghong 3; Liang, Xing-Jie 1,2,4
	2019-04
发表期刊	NATURE NANOTECHNOLOGY
ISSN	1748-3387
卷号	14 期号:4 页码:379-+
发表状态	已发表
DOI	10.1038/s41565-019-0373-6
摘要	Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells. We show that imaging-guided interventional injection of these particles potently inhibits tumour growth in subcutaneous and orthotopic patient-derived xenograft hepatocellular carcinoma models without adverse effects. Our study demonstrates that MitoCAT-g amplifies the oxidative stress in mitochondria and suppresses tumour growth in vivo, representing a promising agent for anticancer applications.
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	'Strategic Priority Research Program' from the Chinese Academy of Sciences[XDA09030301]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000463195700020
出版者	NATURE PUBLISHING GROUP
WOS关键词	ACETIC-ACID INJECTION ; HEPATOCELLULAR-CARCINOMA ; LIVER-CANCER ; GLUTATHIONE ; OXYGEN ; ROS ; APOPTOSIS ; NANOPARTICLES ; SPECTROSCOPY ; MECHANISMS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34158
专题	大科学中心_PI研究组_江怀东组物质科学与技术学院
通讯作者	Li, Jinghong; Liang, Xing-Jie
作者单位	1.Chinese Acad Sci, Lab Controllable Nanopharmaceut, Ctr Excellence Nanosci, Beijing, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 3.Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing, Peoples R China 6.North China Elect Power Univ, Sch Environm & Chem Engn, Beijing, Peoples R China 7.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China 8.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding, Peoples R China
推荐引用方式 GB/T 7714	Gong, Ningqiang,Ma, Xiaowei,Ye, Xiaoxia,et al. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment[J]. NATURE NANOTECHNOLOGY,2019,14(4):379-+.
APA	Gong, Ningqiang.,Ma, Xiaowei.,Ye, Xiaoxia.,Zhou, Qunfang.,Chen, Xiaoai.,...&Liang, Xing-Jie.(2019).Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment.NATURE NANOTECHNOLOGY,14(4),379-+.
MLA	Gong, Ningqiang,et al."Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment".NATURE NANOTECHNOLOGY 14.4(2019):379-+.