Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

doi:10.1038/s41392-023-01588-0

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	Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
	Gao, Chao 1; Jiang, Jingwen 1; Tan, Yuyan 1; Chen, Shengdi1,2
	2023-09-22
发表期刊	SIGNAL TRANSDUCTION AND TARGETED THERAPY (IF:40.8[JCR-2023],40.5[5-Year])
ISSN	2095-9907
EISSN	2059-3635
卷号	8 期号:1
发表状态	已发表
DOI	10.1038/s41392-023-01588-0
摘要	Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions. Microglia both exert protective function by phagocytosing and clearing pathological protein aggregates and play detrimental roles due to excessive uptake of protein aggregates, which would lead to microglial phagocytic ability impairment, neuroinflammation, and eventually neurodegeneration. In addition, peripheral immune cells infiltration shapes microglia into a pro-inflammatory phenotype and accelerates disease progression. Microglia also act as a mobile vehicle to propagate protein aggregates. Extracellular vesicles released from microglia and autophagy impairment in microglia all contribute to pathological progression and neurodegeneration. Thus, enhancing microglial phagocytosis, reducing microglial-mediated neuroinflammation, inhibiting microglial exosome synthesis and secretion, and promoting microglial conversion into a protective phenotype are considered to be promising strategies for the therapy of neurodegenerative diseases. Here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies and Huntington's disease. We also summarize the possible microglia-targeted interventions and treatments against neurodegenerative diseases with preclinical and clinical evidence in cell experiments, animal studies, and clinical trials.
URL	查看原文
收录类别	SCI
语种	英语
资助项目	This research was funded by the National Natural Science Foundation of China (81971187, 82171401, 81971183, and 82101477), Shanghai Municipal Science and Technology Major Project (2018SHZDZX05) and Innovation Program of Shanghai Municipal Education Commiss["81971187","82171401","81971183","82101477"] ; National Natural Science Foundation of China[2018SHZDZX05] ; Shanghai Municipal Science and Technology Major Project[2017-01-07-00-01-E00046]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001071173200001
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/337712
专题	免疫化学研究所免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Tan, Yuyan; Chen, Shengdi
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200025, Peoples R China 2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Lab Translat Res Neurodegenerat Dis, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Gao, Chao,Jiang, Jingwen,Tan, Yuyan,et al. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1).
APA	Gao, Chao,Jiang, Jingwen,Tan, Yuyan,&Chen, Shengdi.(2023).Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1).
MLA	Gao, Chao,et al."Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023).