Multifunctional optical tomography system combining surface extraction and 3D fluorescence reconstruction

doi:10.1117/12.2692026

	Multifunctional optical tomography system combining surface extraction and 3D fluorescence reconstruction
	Wu, Yanan1 ; Gao, Shengyu1 ; Li, Linlin1 ; Zhang, Jianru1 ; Hu, Qian2 ; Lou, Xin1 ; Zhu, Xinjun2 ; Jiang, Jiahua3,4 ; Ren, Wuwei1
	2023
会议录名称	PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING
ISSN	0277-786X
卷号	12753
DOI	10.1117/12.2692026
摘要	Macroscopic-level diffuse optical imaging has been widely used in small animal imaging for preclinical research. Due to severe light scattering, 3D reconstruction in diffuse optics is highly ill-posed and sensitive to small noise in measurement. Bringing prior information such as the inner structural or surface information of the imaging object may largely reduce the ill-posed nature of the inverse problem and improve the reconstruction accuracy. Most existing solutions use additional equipment or multimodal techniques (e.g., CT, MRI, etc.). However, these methods pose new challenges such as increased cost and image alignment between different modalities. Herein, we present a novel compact optical tomography system that enables surface extraction using a single programmable scanning module and pinhole modeling. Experiments on phantom and mice show that the system is capable of achieving high-fidelity surface extraction with a minimal error of less than 0.1 mm, which in turn improves the accuracy of 3D fluorescence reconstruction. © 2023 SPIE.
关键词	Computerized tomography Extraction Fluorescence Inverse problems Light scattering Mammals Medical applications Optical tomography 3d fluorescences Diffuse optical Fluorescence molecular tomography Images reconstruction Macroscopic levels Optical imaging Small animal imaging Structured Light Surface extraction Tomography system
会议名称	2nd Conference on Biomedical Photonics and Cross-Fusion, BPC 2023
会议地点	Shanghai, China
会议日期	June 8, 2023 - June 10, 2023
收录类别	EI
语种	英语
出版者	SPIE
EI入藏号	20233814733642
EI主题词	Image reconstruction
EISSN	1996-756X
EI分类号	723.5 Computer Applications ; 741.1 Light/Optics ; 741.3 Optical Devices and Systems ; 802.3 Chemical Operations
原始文献类型	Conference article (CA)
文献类型	会议论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/335595
专题	信息科学与技术学院物质科学与技术学院信息科学与技术学院_PI研究组_娄鑫组物质科学与技术学院_博士生信息科学与技术学院_硕士生信息科学与技术学院_博士生物质科学与技术学院_PI研究组_朱幸俊组信息科学与技术学院_PI研究组_任无畏组数学科学研究所_PI研究组(P)_姜嘉骅组
通讯作者	Ren, Wuwei
作者单位	1.School of Information Science and Technology, ShanghaiTech University, Shanghai; 201210, China; 2.School of Physical Science and Technology, ShanghaiTech University, Shanghai; 201210, China; 3.Institute of Mathematical Science, ShanghaiTech University, Shanghai; 201210, China; 4.School of Mathematics, University of Birmingham, Edgbaston; B15 2QN, United Kingdom
第一作者单位	信息科学与技术学院
通讯作者单位	信息科学与技术学院
第一作者的第一单位	信息科学与技术学院
推荐引用方式 GB/T 7714	Wu, Yanan,Gao, Shengyu,Li, Linlin,et al. Multifunctional optical tomography system combining surface extraction and 3D fluorescence reconstruction[C]:SPIE,2023.