Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases

doi:10.1016/j.sbi.2023.102672

	Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases
	Chen, Xingchen 1; Ding, Jianping1,2
	2023-10-01
发表期刊	CURRENT OPINION IN STRUCTURAL BIOLOGY (IF:6.1[JCR-2023],6.0[5-Year])
ISSN	0959-440X
EISSN	1879-033X
卷号	82
发表状态	已发表
DOI	10.1016/j.sbi.2023.102672
摘要	Eukaryotic NAD-dependent isocitrate dehydrogenases (NAD-IDHs) are mitochondria-localized enzymes which catalyze the oxidative decarboxylation of isocitrate to a-ketoglutarate using NAD as a cofactor. In mammals, NAD-IDHs (or IDH3) consist of three types of subunits (a, b, and g), and exist as (a2bg)2 heterooctamer. Mammalian NAD-IDHs are regulated allosteri-cally and/or competitively by a diversity of metabolites including citrate, ADP, ATP, NADH, and NADPH, which are associated with cellular metabolite flux, energy demands, and redox status. Proper assembly of the component subunits is essential for the catalysis and regulation of the enzymes. Recently, crystal structures of human IDH3 have been solved in apo form and in complex with various ligands, revealing the molecular mecha-nisms for the assembly, catalysis, and regulation of the enzyme.
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[32071190] ; null[XDB37030305]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001057514500001
出版者	CURRENT BIOLOGY LTD
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/327925
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_丁建平组
通讯作者	Ding, Jianping
作者单位	1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Huaxia Zhong Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Xingchen,Ding, Jianping. Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2023,82.
APA	Chen, Xingchen,&Ding, Jianping.(2023).Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases.CURRENT OPINION IN STRUCTURAL BIOLOGY,82.
MLA	Chen, Xingchen,et al."Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases".CURRENT OPINION IN STRUCTURAL BIOLOGY 82(2023).