Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia

doi:10.1038/s41398-023-02520-4

	Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia
	Zhao, Jiajia 1; Huang, Chu-Chung 2,3; Zhang, Yajuan4 ; Liu, Yuchen 1; Tsai, Shih-Jen 5,6,7; Lin, Ching-Po 8,9; Lo, Chun-Yi Zac 10
	2023-06-21
发表期刊	TRANSLATIONAL PSYCHIATRY (IF:5.8[JCR-2023],6.3[5-Year])
ISSN	2158-3188
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41398-023-02520-4
摘要	Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread impairment of structural and functional integration has been demonstrated in schizophrenia. Although white matter (WM) microstructural abnormalities have been commonly reported in schizophrenia, the dysfunction of WM as well as the relationship between structure and function in WM remains uncertain. In this study, we proposed a novel structure-function coupling measurement to reflect neuronal information transfer, which combined spatial-temporal correlations of functional signals with diffusion tensor orientations in the WM circuit from functional and diffusion magnetic resonance images (MRI). By analyzing MRI data from 75 individuals with schizophrenia (SZ) and 89 healthy volunteers (HV), the associations between structure and function in WM regions in schizophrenia were examined. Randomized validation of the measurement was performed in the HV group to confirm the capacity of the neural signal transferring along the WM tracts, referring to quantifying the association between structure and function. Compared to HV, SZ showed a widespread decrease in the structure-function coupling within WM regions, involving the corticospinal tract and the superior longitudinal fasciculus. Additionally, the structure-function coupling in the WM tracts was found to be significantly correlated with psychotic symptoms and illness duration in schizophrenia, suggesting that abnormal signal transfer of neuronal fiber pathways could be a potential mechanism of the neuropathology of schizophrenia. This work supports the dysconnectivity hypothesis of schizophrenia from the aspect of circuit function, and highlights the critical role of WM networks in the pathophysiology of schizophrenia.
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收录类别	SCI
语种	英语
资助项目	Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; National Natural Science Foundation of China["82201720","NSTC 112-2321-B-A49-008-"] ; National Science and Technology Council, Taiwan[2022ZD0213400] ; null[82271627]
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001049943700001
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/325790
专题	生物医学工程学院生物医学工程学院_PI研究组_张寒组
通讯作者	Huang, Chu-Chung; Lo, Chun-Yi Zac
作者单位	1.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China 2.East China Normal Univ, Inst Cognit Neurosci, Shanghai Key Lab Brain Funct Genom, Minist Educ,Sch Psychol & Cognit Sci,Affiliated Me, Shanghai, Peoples R China 3.Shanghai Changning Mental Hlth Ctr, Shanghai, Peoples R China 4.ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China 5.Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan 6.Natl Yang Ming Chiao Tung Univ, Fac Med, Div Psychiat, Taipei, Taiwan 7.Natl Yang Ming Chiao Tung Univ, Inst Brain Sci, Taipei, Taiwan 8.Natl Yang Ming Chiao Tung Univ, Inst Neurosci, Taipei, Taiwan 9.Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan 10.Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan, Taiwan
推荐引用方式 GB/T 7714	Zhao, Jiajia,Huang, Chu-Chung,Zhang, Yajuan,et al. Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2023,13(1).
APA	Zhao, Jiajia.,Huang, Chu-Chung.,Zhang, Yajuan.,Liu, Yuchen.,Tsai, Shih-Jen.,...&Lo, Chun-Yi Zac.(2023).Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia.TRANSLATIONAL PSYCHIATRY,13(1).
MLA	Zhao, Jiajia,et al."Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia".TRANSLATIONAL PSYCHIATRY 13.1(2023).