Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs

doi:10.1038/s41467-023-40321-x

KMS > 免疫化学研究所

	Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs
	Niu, Jun1,2,3,4 ; Wang, Qi1,2 ; Zhao, Wenwen1,2 ; Meng, Bing1,2 ; Xu, Youwei1,2 ; Zhang, Xianfang1,2 ; Feng, Yi 5; Qi, Qilian1,2 ; Hao, Yanling 5; Zhang, Xuan1,2 ; Liu, Ying 5; Xiang, Jiangchao1,2 ; Shao, Yiming 5,6; Yang, Bei1,2,7
	2023-08-04
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	14 期号:1
发表状态	已发表
DOI	10.1038/s41467-023-40321-x
摘要	["Envelope glycoproteins from Asia prevalent HIV-1 subtypes, CRF01_AE and CRF07_BC, remain less explored. Here, the authors reveal the unique features of their V1 regions, associate them with the resistance to certain broad neutralising antibodies (bNAbs), and unravel the epitope and mechanism of a bNAb from CRF01_AE infected individuals.","Structure-guided immunofocusing HIV-1 vaccine design entails a comprehensive understanding of Envs from diverse HIV-1 subtypes, including circulating recombinant forms (CRFs). Here, we present the cryo-EM structures of Envs from two Asia prevalent CRFs (CRF01_AE and CRF07_BC) at 3.0 and 3.5 & ANGS;. We compare the structures and glycosylation patterns of Envs from different subtypes and perform cross-clade statistical analyses to reveal the unique features of CRF01_AE V1 region, which are associated with the resistance to certain bNAbs. We also solve a 4.1 & ANGS; cryo-EM structure of CRF01_AE Env in complex with F6, the first bNAb from CRF01_AE-infected individuals. F6 recognizes a gp120-gp41 spanning epitope to allosterically destabilize the Env trimer apex and weaken inter-protomer packing, which in turn hinders the receptor binding and induces Env trimer disassembly, demonstrating a dual mechanism of neutralization. These findings broaden our understanding of CRF Envs and shed lights on immunofocusing HIV-1 vaccine design."]
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收录类别	SCI
语种	英语
资助项目	MoST["2018ZX10731-101-001-010","2018ZX10731-101","2019YFA0802804","2016YFE0107600"] ; National Natural Science Foundation of China (NSFC)[32070170]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001042606700006
出版者	NATURE PORTFOLIO
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/325789
专题	免疫化学研究所生命科学与技术学院生命科学与技术学院_PI研究组_陈佳组 iHuman研究所_PI研究组_刘志杰组生命科学与技术学院_博士生免疫化学研究所_PI研究组_杨贝组
通讯作者	Shao, Yiming; Yang, Bei
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China 6.Changping Lab, Beijing 102206, Peoples R China 7.Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China
第一作者单位	免疫化学研究所; 生命科学与技术学院
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Niu, Jun,Wang, Qi,Zhao, Wenwen,et al. Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Niu, Jun.,Wang, Qi.,Zhao, Wenwen.,Meng, Bing.,Xu, Youwei.,...&Yang, Bei.(2023).Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs.NATURE COMMUNICATIONS,14(1).
MLA	Niu, Jun,et al."Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs".NATURE COMMUNICATIONS 14.1(2023).