Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine

doi:10.1038/s42003-023-05149-7

	Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine
	Cao, Silu 1,2,3,4; Wu, Yiling5 ; Gao, Zilong 6,7,8; Tang, Jinxuan 1,2,3,4; Xiong, Lize 1,2,3,4; Hu, Ji5 ; Li, Cheng 1,2,3,4
	2023-08-02
发表期刊	COMMUNICATIONS BIOLOGY (IF:5.2[JCR-2023],5.6[5-Year])
EISSN	2399-3642
卷号	6 期号:1
发表状态	已发表
DOI	10.1038/s42003-023-05149-7
摘要	["Postoperative delirium (POD) is a complicated and harmful clinical syndrome. Traditional behaviour analysis mostly focuses on static parameters. However, animal behaviour is a bottom-up and hierarchical organizational structure composed of time-varying posture dynamics. Spontaneous and task-driven behaviours are used to conduct comprehensive profiling of behavioural data of various aspects of model animals. A machine-learning based method is used to assess the effect of dexmedetomidine. Fourteen statistically different spontaneous behaviours are used to distinguish the non-POD group from the POD group. In the task-driven behaviour, the non-POD group has greater deep versus shallow investigation preference, with no significant preference in the POD group. Hyperactive and hypoactive subtypes can be distinguished through pose evaluation. Dexmedetomidine at a dose of 25 mu g kg(-1) reduces the severity and incidence of POD. Here we propose a multi-scaled clustering analysis framework that includes pose, behaviour and action sequence evaluation. This may represent the hierarchical dynamics of delirium-like behaviours.","A machine learning-based method developed to analyse postoperative delirium (POD)-like behaviour in rodents shows that dexmedetomidine can reduce the severity and incidence of POD in an animal model"]
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82271223] ; Shanghai Municipal Committee of Science and Technology[23XD1422900] ; Shanghai Fourth People's Hospital, School of Medicine, Tongji University["sykyqd01902","SY-XKZT-2021-2001"]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS类目	Biology ; Multidisciplinary Sciences
WOS记录号	WOS:001048682700005
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/323566
专题	生命科学与技术学院生命科学与技术学院_PI研究组_胡霁组生命科学与技术学院_本科生
通讯作者	Hu, Ji; Li, Cheng
作者单位	1.Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Anesthesiol & Perioperat Med, Shanghai 200434, Peoples R China 2.Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain like Intelligence, Sch Med, Shanghai 200434, Peoples R China 3.Tongji Univ, Clin Res Ctr Anesthesiol & Perioperat Med, Shanghai 200434, Peoples R China 4.Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Shanghai 200434, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Westlake Univ, Sch Life Sci, Hangzhou 310024, Peoples R China 7.Westlake Univ, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou 310024, Peoples R China 8.Chinese Inst Brain Res, Beijing 102206, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Cao, Silu,Wu, Yiling,Gao, Zilong,et al. Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine[J]. COMMUNICATIONS BIOLOGY,2023,6(1).
APA	Cao, Silu.,Wu, Yiling.,Gao, Zilong.,Tang, Jinxuan.,Xiong, Lize.,...&Li, Cheng.(2023).Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine.COMMUNICATIONS BIOLOGY,6(1).
MLA	Cao, Silu,et al."Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine".COMMUNICATIONS BIOLOGY 6.1(2023).