Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease

doi:10.1038/s41531-023-00554-5

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	Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease
	Huang, Pei 1; Zhang, Pingchen 1; Du, Juanjuan 1; Gao, Chao 1; Liu, Jin 1; Tan, Yuyan 1; Chen, Shengdi1,2
	2023-07-17
发表期刊	NPJ PARKINSONS DISEASE (IF:6.7[JCR-2023],7.3[5-Year])
EISSN	2373-8057
卷号	9 期号:1
发表状态	已发表
DOI	10.1038/s41531-023-00554-5
摘要	Diagnosis of essential tremor (ET) at an early stage can be difficult, especially when distinguishing it from healthy controls (HCs) and Parkinson's disease (PD). Recently, stool sample analysis of gut microbiota and its metabolites provides new ways to detect novel biomarkers for neurodegenerative diseases. Short-chain fatty acids (SCFAs), as the main metabolites of gut microbiota, were reduced in the feces of PD. However, fecal SCFAs in ET have never been investigated. We aimed to investigate the fecal SCFA levels in ET, assess their relationships with clinical symptoms and gut microbiota, and identify their potential diagnostic abilities. Fecal SCFAs and gut microbiota in 37 ET, 37 de novo PD and 35 HC were measured. Constipation, autonomic dysfunction and tremor severity were evaluated by scales. ET had lower fecal propionic, butyric and isobutyric acid levels than HC. Combined propionic, butyric and isobutyric acid distinguished ET from HC with an AUC of 0.751 (95% CI: 0.634-0.867). ET had lower fecal isovaleric and isobutyric acid levels than PD. Isovaleric and isobutyric acid differentiated ET from PD with an AUC of 0.743 (95% CI: 0.629-0.857). Fecal propionic acid was negatively correlated with constipation and autonomic dysfunction. Isobutyric and isovaleric acid were negatively associated with tremor severity. Lowered fecal SCFAs were related to a decreased abundance of Faecalibacterium and Catenibacterium in ET. In conclusion, fecal SCFAs were decreased in ET and correlated with clinical severity and gut microbiota changes. Fecal propionic, butyric, isobutyric and isovaleric acid might be potential diagnostic and differential diagnostic biomarkers for ET.
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China["81971187","82171401","81971183","81801267"] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:001031317500002
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/321471
专题	免疫化学研究所免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Tan, Yuyan; Chen, Shengdi
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China 2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Lab Translat Res Neurodegenerat Dis, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Huang, Pei,Zhang, Pingchen,Du, Juanjuan,et al. Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease[J]. NPJ PARKINSONS DISEASE,2023,9(1).
APA	Huang, Pei.,Zhang, Pingchen.,Du, Juanjuan.,Gao, Chao.,Liu, Jin.,...&Chen, Shengdi.(2023).Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease.NPJ PARKINSONS DISEASE,9(1).
MLA	Huang, Pei,et al."Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson's disease".NPJ PARKINSONS DISEASE 9.1(2023).